Clemson vs Wake Forest College Basketball Prediction, Odds, Picks, Best Bets for ACC Tournament

The No. 5 seed Clemson Tigers (22-9, 12-6 ACC) and the No. 13 seed Wake Forest Demon Deacons (17-15, 7-11 ACC) meet in the ACC tournament Wednesday at Spectrum Center, tipping off at 9:30 p.m. ET.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Clemson vs. Wake Forest Game Info and Odds

• Game day: Wednesday, March 11, 2026
• Game time: 9:30 p.m. ET
• TV channel: ESPN2
• Location: Charlotte, North Carolina
• Arena: Spectrum Center

Clemson vs. Wake Forest Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Clemson win (69.7%)

Before placing a bet on Wednesday's Clemson-Wake Forest spread (Clemson -5.5) or total (141.5 points), take a look at the betting insights and trends below.

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Clemson vs. Wake Forest: ATS Betting Stats and Trends

• Clemson is 16-15-0 ATS this season.
• Wake Forest is 15-17-0 ATS this season.
• When the spread is set as 5.5 or more this season, Clemson (5-8) covers a lower percentage of those games when it is the favorite (38.5%) than Wake Forest (5-4) does as the underdog (55.6%).
• The Tigers have covered the spread in a lower percentage of their home games than road games. They have covered seven times in 16 games at home, and they've covered seven times in 11 games when playing on the road.
• In 2025-26 against the spread, the Demon Deacons have a better winning percentage at home (.444, 8-10-0 record) than on the road (.333, 3-6-0).
• Clemson has 10 wins against the spread in 18 conference games this season.
• Wake Forest's ACC record against the spread is 9-10-0.

Clemson vs. Wake Forest: Moneyline Betting Stats

• Clemson has been the moneyline favorite in 23 games this season and has come away with the win 18 times (78.3%) in those contests.
• This season, the Tigers have come away with a win nine times in 11 chances when named as a favorite of at least -230 or better on the moneyline.
• Wake Forest has gone 3-12 in games it was listed as the moneyline underdog (winning 20% of those games).
• The Demon Deacons have not yet won a game when it entered play as a moneyline underdog with odds of +188 or longer in eight chances.
• Oddsmakers have implied with the moneyline set for this matchup that Clemson has a 69.7% chance of pulling out a win.

Clemson vs. Wake Forest Head-to-Head Comparison

• Clemson's +254 scoring differential (outscoring opponents by 8.2 points per game) is a result of scoring 74.5 points per game (217th in college basketball) while giving up 66.3 per contest (23rd in college basketball).
• RJ Godfrey is 770th in the country with a team-leading 11.7 points per game.
• Wake Forest is outscoring opponents by 2.1 points per game, with a +68 scoring differential overall. It puts up 79.4 points per game (98th in college basketball) and gives up 77.3 per contest (269th in college basketball).
• Juke Harris leads Wake Forest, scoring 21.3 points per game (15th in college basketball).
• The Tigers record 31.7 rebounds per game (197th in college basketball) while conceding 29.2 per contest to their opponents. They outrebound opponents by 2.5 boards per game.
• Carter Welling's 5.5 rebounds per game lead the Tigers and rank 418th in college basketball action.
• The Demon Deacons record 29.8 rebounds per game (291st in college basketball) while allowing 31.7 per outing to opponents. They are outrebounded by 1.9 boards per game.
• Harris tops the team with 6.7 rebounds per game (196th in college basketball).
• Clemson averages 102.2 points per 100 possessions on offense (77th in college basketball), and allows 91.0 points per 100 possessions (73rd in college basketball).
• The Demon Deacons' 100.1 points per 100 possessions on offense rank 118th in college basketball, and the 97.4 points they concede per 100 possessions rank 243rd in college basketball.

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