Clemson vs SMU Prediction, Odds, Picks, Best Bets for Week 8 2025

College football's Saturday slate includes the Clemson Tigers facing the SMU Mustangs.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Clemson vs SMU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-164) | SMU: (+138)
• Spread: Clemson: -3.5 (-110) | SMU: +3.5 (-110)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Clemson vs SMU Betting Trends

• Clemson has won twice against the spread this season.
• Clemson has two wins ATS (2-4) as a 3.5-point or higher favorite in 2025.
• Two of six Clemson games have hit the over this year.
• SMU has posted one win against the spread this year.
• SMU is winless ATS (0-1) when playing as at least 3.5-point underdogs this season.
• One SMU game (out of five) has hit the over this season.

Clemson vs SMU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (55.4%)

Clemson vs SMU Point Spread

Clemson is favored by 3.5 points versus SMU. Clemson is -110 to cover the spread, while SMU is -110.

Clemson vs SMU Over/Under

A combined point total of 49.5 has been set for Clemson-SMU on Oct. 18, with the over at -110 and the under at -110.

Clemson vs SMU Moneyline

Looking at the moneyline for Clemson-SMU, Clemson is the favorite at -164, and SMU is +138.

Clemson vs. SMU Points Insights

Clemson vs. SMU Game Info

• Game day: Saturday, October 18, 2025
• Game time: 3:30 p.m. ET
• TV channel: ACC Network
• Location: Clemson, South Carolina
• Stadium: Memorial Stadium (Clemson, SC)

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Check out even more in-depth Clemson vs. SMU analysis on FanDuel Research.