Cincinnati vs Iowa State Prediction, Odds, Picks, Best Bets for Week 6 2025

The Saturday schedule in college football includes a matchup between the Cincinnati Bearcats and the Iowa State Cyclones.

We've got you covered, in terms of the most important info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Cincinnati vs Iowa State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Cincinnati: (-125) | Iowa State: (+104)
• Spread: Cincinnati: -1.5 (-115) | Iowa State: +1.5 (-105)
• Total: 55.5 -- Over: (-110) | Under: (-110)

Cincinnati vs Iowa State Betting Trends

• Against the spread, Cincinnati is 3-1-0 this year.
• Cincinnati owns one win ATS (1-1) as a 1.5-point favorite or greater this season.
• Out of four Cincinnati games so far this season, three have gone over the total.
• Against the spread, Iowa State is 3-2-0 this year.
• Iowa State has yet to lose ATS (1-0) as a 1.5-point underdog or more this year.
• A pair of Iowa State five games in 2025 have gone over the point total.

Cincinnati vs Iowa State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (54.5%)

Cincinnati vs Iowa State Point Spread

Cincinnati is favored by 1.5 points versus Iowa State. Cincinnati is -115 to cover the spread, while Iowa State is -105.

Cincinnati vs Iowa State Over/Under

An over/under of 55.5 has been set for Cincinnati-Iowa State on Oct. 4, with the over being -110 and the under -110.

Cincinnati vs Iowa State Moneyline

Cincinnati is a -125 favorite on the moneyline, while Iowa State is a +104 underdog.

Cincinnati vs. Iowa State Points Insights

Cincinnati vs. Iowa State Game Info

• Game day: Saturday, October 4, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN2
• Location: Cincinnati, Ohio
• Stadium: Nippert Stadium

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