Cincinnati vs Iowa State Prediction, Odds, Picks, Best Bets for Week 6 2025

College football's Saturday schedule includes the Cincinnati Bearcats facing the Iowa State Cyclones.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information about today's NCAA football betting odds.

Cincinnati vs Iowa State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Cincinnati: (-108) | Iowa State: (-108)
• Spread: Cincinnati: -1.5 (-106) | Iowa State: +1.5 (-114)
• Total: 55.5 -- Over: (-115) | Under: (-105)

Cincinnati vs Iowa State Betting Trends

• Cincinnati is 3-1-0 against the spread this season.
• Cincinnati has won once ATS (1-1) as a 1.5-point or higher favorite this season.
• There have been three Cincinnati games (of four) that hit the over this season.
• Iowa State has covered the spread three times in five games.
• Iowa State has covered every time (1-0) as a 1.5-point or greater underdog this season.
• Two Iowa State games (of five) have gone over the point total this year.

Cincinnati vs Iowa State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (54.2%)

Cincinnati vs Iowa State Point Spread

Cincinnati is favored by 1.5 points (-106 to cover) in this matchup. Iowa State, the underdog, is -114.

Cincinnati vs Iowa State Over/Under

A combined point total of 55.5 has been set for Cincinnati-Iowa State on Oct. 4, with the over at -115 and the under at -105.

Cincinnati vs Iowa State Moneyline

The Cincinnati vs Iowa State moneyline has Iowa State as a -108 favorite, while Cincinnati is a -108 underdog.

Cincinnati vs. Iowa State Points Insights

Cincinnati vs. Iowa State Game Info

• Game day: Saturday, October 4, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN2
• Location: Cincinnati, Ohio
• Stadium: Nippert Stadium

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Check out even more in-depth Cincinnati vs. Iowa State analysis on FanDuel Research.