Christian McCaffrey Fantasy Football Week 6: Stats and Projections vs. Buccaneers

Running back Christian McCaffrey faces a matchup against the eighth-ranked run defense in the NFL (92.4 yards conceded per game) in Week 6, when his San Francisco 49ers take on the Tampa Bay Buccaneers, Sunday at 4:25 p.m. ET.

Daily fantasy players, is McCaffrey worth a look for his upcoming matchup against the Buccaneers? Scroll down, because we can help you make the right decision.

Thinking about playing McCaffrey this week? Start building your FanDuel fantasy football lineup today!

Christian McCaffrey Week 6 Fantasy Football Projection

• Matchup: San Francisco 49ers at Tampa Bay Buccaneers
• Game Date: October 12, 2025
• Game Time: 4:25 p.m.
• Projected Fantasy Points: 17.6
• PPR Projected Fantasy Points: 20.7
• Projected Rushing Yards: 74.10
• Projected Rushing TDs: 0.60
• Projected Receiving Yards: 51.34
• Projected Receiving TDs: 0.29

Projections provided by numberFire

McCaffrey Fantasy Performance

• At the RB position, McCaffrey has been one of the top players in fantasy, as he ranks third in the NFL with 17.0 fantasy points per game (84.9 total points). Overall, he is 15th in fantasy points.
• In his last three games, McCaffrey has picked up 54.0 fantasy points (18.0 per game), running for 158 yards and scoring zero touchdowns on 56 carries. He has also contributed 262 yards on 24 catches (35 targets) with two TDs as a receiver.
• The high point of McCaffrey's fantasy season was a Week 4 performance against the Jacksonville Jaguars, when he tallied 20.1 fantasy points (17 receptions, 49 yards).
• From a fantasy perspective, Christian McCaffrey disappointed his fantasy managers against the Arizona Cardinals in Week 3, when he mustered only 14.0 fantasy points (17 carries, 52 yards; 10 receptions, 88 yards). It was his worst fantasy effort of the season.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Buccaneers Defensive Performance

• One player has recorded over 300 yards passing in a game against Tampa Bay this year.
• A total of Five players have thrown for at least one TD against the Buccaneers this season.
• A total of three players have thrown for two or more TDs versus Tampa Bay this season.
• The Buccaneers have allowed only one player to throw for three or more TDs in a game this year.
• Tampa Bay has allowed two players to put up more than 100 yards receiving in a game this season.
• The Buccaneers have given up a TD catch by eight players this year.
• Tampa Bay has allowed two or more receiving TDs to two players this season.
• The Buccaneers have not given up more than 100 yards rushing to an opposing player this season.
• Tampa Bay has allowed four players to score at least one rushing touchdown against them this season.
• The Buccaneers have not given up more than one rushing TD to an opposing player this year.

Want more data and analysis on Christian McCaffrey? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.