Celtics vs. Pacers Prediction, Odds, Picks, Best Bets for Dec. 22

Celtics vs. Pacers Game Info

• Date: Monday, December 22, 2025
• Time: 7:30 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: FDSIN and NBCS-BOS

The Indiana Pacers (6-22) will look to break a four-game losing streak when they visit the Boston Celtics (17-11) on Monday, December 22, 2025 at TD Garden as big, 12-point underdogs. The game airs at 7:30 p.m. ET on FDSIN and NBCS-BOS. The point total is 225.5 for the matchup.

Celtics vs. Pacers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. Pacers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (77.5%)

Celtics vs. Pacers Betting Trends

• The Celtics have covered the spread 16 times this season (16-11-1).
• The Pacers have 14 wins against the spread in 28 games this season.
• Games involving the Celtics have hit the over 13 times this season.
• Pacers games this season have hit the over 11 times in 28 opportunities (39.3%).
• Boston has covered the spread in the same percentage of home games as road games (57.1%). It has covered eight times in 14 games when playing at home and eight times in 14 games on the road.
• The Celtics have eclipsed the over/under in a higher percentage of games at home (57.1%) than road tilts (35.7%).
• Against the spread, Indiana has performed better at home (9-6-0) than away (5-8-0).
• Pacers games have finished above the over/under more frequently at home (eight times out of 15) than away (three of 13) this season.

Celtics Leaders

• Jaylen Brown averages 29.3 points, 6.3 boards and 5 assists.
• Derrick White averages 18.2 points, 4.1 boards and 5.1 assists.
• Payton Pritchard is averaging 17 points, 4.4 boards and 5.2 assists. At the other end, he averages 0.7 steals and 0.1 blocked shots.
• Neemias Queta is averaging 10.1 points, 7.9 rebounds and 1.6 assists.
• Anfernee Simons is averaging 13.1 points, 2.2 boards and 2.4 assists. Defensively, he averages 0.5 steals and 0.1 blocked shots.

Pacers Leaders

• Pascal Siakam is averaging 23.8 points, 6.7 rebounds and 4 assists for the Pacers.
• Andrew Nembhard's numbers on the season are 17.5 points, 2.3 boards and 6.4 assists per contest. He is making 42.5% of his shots from the floor and 36.4% from beyond the arc, with an average of 1.8 treys.
• Jay Huff averages 8.1 points, 4 boards and 1.3 assists. He is draining 42.2% of his shots from the field and 30.5% from beyond the arc, with 1.4 triples per contest.
• Jarace Walker averages 9.4 points, 4.8 boards and 2 assists. He is draining 34.4% of his shots from the floor and 30.8% from 3-point range, with 1.4 treys per game.
• Per game, Isaiah Jackson provides the Pacers 7.6 points, 6.1 rebounds and 0.9 assists, plus 0.8 steals and 0.8 blocks.

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