Celtics vs. Cavaliers Prediction, Odds, Picks, Best Bets for Oct. 29

Celtics vs. Cavaliers Game Info

• Date: Wednesday, October 29, 2025
• Time: 7 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: ESPN, NBCS-BOS, and FDSOH

The Cleveland Cavaliers (3-1) are 4.5-point favorites as they try to continue a three-game win streak when they visit the Boston Celtics (1-3) on Wednesday, October 29, 2025 at TD Garden. The contest airs at 7 p.m. ET on ESPN, NBCS-BOS, and FDSOH. The matchup has a point total of 231.5.

Celtics vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (55.8%)

Celtics vs. Cavaliers Betting Trends

• The Cavaliers went 47-33-2 ATS last season.
• As a 4.5-point underdog or greater, the Celtics had one win ATS (1-1) last season.
• The Cavaliers and their opponents combined to hit the over 50 out of 82 times last season.
• There were 37 Celtics games (out of 82) that hit the over last year.
• Against the spread last year, Cleveland played worse when played at home, covering 23 times in 41 home games, and 24 times in 41 road games.
• Against the spread last season, Boston had better results on the road (21-19-1) than at home (18-23-0).

Cavaliers Leaders

• Per game, Donovan Mitchell put up points, 4.5 rebounds and 5 assists last season. He also averaged 1.3 steals and 0.2 blocks.
• Per game, Evan Mobley put up 18.5 points, 9.3 rebounds and 3.2 assists. He also delivered 0.9 steals and 1.6 blocks (fourth in NBA).
• Darius Garland's numbers last season were 20.6 points, 2.9 boards and 6.7 assists per game. He made 47.2% of his shots from the field and 40.1% from beyond the arc, with an average of 2.8 treys.
• Jarrett Allen averaged 13.5 points, 9.7 rebounds and 1.9 assists. He drained 70.6% of his shots from the floor (first in NBA).
• De'Andre Hunter recorded 17 points, 4 boards and 1.4 assists. He drained 47% of his shots from the floor and 40.5% from beyond the arc, with 2.5 triples per contest.

Celtics Leaders

• Jayson Tatum recorded 26.8 points last season, plus 6 assists and 8.7 boards.
• Derrick White averaged 16.4 points, 4.5 boards and 4.8 assists last year. At the other end, he posted 0.9 steals and 1.1 blocked shots.
• Jaylen Brown's numbers last season were 22.2 points, 5.8 rebounds and 4.5 assists per contest, shooting 46.3% from the floor and 32.4% from downtown, with an average of 1.8 made treys.
• Anfernee Simons posted 19.3 points, 2.7 rebounds and 4.8 assists.
• Payton Pritchard put up 14.3 points, 3.5 assists and 3.8 rebounds.

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