Celtics vs. Cavaliers Prediction, Odds, Picks, Best Bets for Oct. 29

Celtics vs. Cavaliers Game Info

• Date: Wednesday, October 29, 2025
• Time: 7 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: ESPN, NBCS-BOS, and FDSOH

The Cleveland Cavaliers (3-1) are 3.5-point favorites as they attempt to continue a three-game win streak when they visit the Boston Celtics (1-3) on Wednesday, October 29, 2025 at TD Garden. The contest airs at 7 p.m. ET on ESPN, NBCS-BOS, and FDSOH. The over/under for the matchup is 233.5.

Celtics vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (54.7%)

Celtics vs. Cavaliers Betting Trends

• The Cavaliers won 47 games against the spread last season, while failing to cover or pushing 35 times.
• The Celtics had two wins ATS (2-1) as a 3.5-point underdog or greater last season.
• The Cavaliers and their opponents combined to go over the point total 50 out of 82 times last season.
• There were 37 Celtics games (out of 82) that hit the over last year.
• Cleveland owned a worse record against the spread when playing at home (23-17-1) than it did in road games (24-16-1) last season.
• In 2024-25 against the spread, Boston had a lower winning percentage at home (.439, 18-23-0 record) than on the road (.512, 21-19-1).

Cavaliers Leaders

• Donovan Mitchell's numbers last season were 24.0 points, 4.5 rebounds and 5.0 assists per contest. He also sank 44.3% of his shots from the floor and 36.8% from beyond the arc, with an average of 3.3 triples (eighth in league).
• Evan Mobley's numbers last season were 18.5 points, 9.3 rebounds and 3.2 assists per contest. He drained 55.7% of his shots from the field and 37.0% from beyond the arc, with an average of 1.2 triples.
• Darius Garland's stats last season included 20.6 points, 2.9 rebounds and 6.7 assists per contest. He drained 47.2% of his shots from the field and 40.1% from beyond the arc, with an average of 2.8 treys.
• Jarrett Allen recorded 13.5 points, 9.7 rebounds and 1.9 assists. He sank 70.6% of his shots from the floor (first in NBA).
• De'Andre Hunter's stats last season included 17.0 points, 4.0 rebounds and 1.4 assists per contest. He made 47.0% of his shots from the field and 40.5% from 3-point range, with an average of 2.5 triples.

Celtics Leaders

• Jayson Tatum recorded 26.8 points, 6.0 assists and 8.7 boards last season.
• Derrick White collected 16.4 points, 4.5 boards and 4.8 assists last season. Defensively, he delivered 0.9 steals and 1.1 blocked shots.
• Jaylen Brown averaged 22.2 points, 5.8 boards and 4.5 assists, shooting 46.3% from the floor and 32.4% from beyond the arc, with 1.8 made treys per contest.
• Anfernee Simons collected 19.3 points, 2.7 boards and 4.8 assists. Defensively, he delivered 0.9 steals and 0.1 blocked shots.
• Payton Pritchard put up 14.3 points, 3.8 rebounds and 3.5 assists.

For more NBA betting insights, check out FanDuel Research's NBA home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Watch FanDuel TV's NBA show "Run It Back" with Lou Williams, Michelle Beadle, DeMarcus "Boogie" Cousins and Chandler Parsons weekdays at 10am ET on FanDuel TV, the Run It Back YouTube page, or download the podcast here: fanduel.com/research/tv-and-podcast.