Celtics vs. 76ers Prediction, Odds, Picks, Best Bets for Oct. 22

Celtics vs. 76ers Game Info

• Date: Wednesday, October 22, 2025
• Time: 7:30 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: NBCS-BOS and NBCS-PH

The Boston Celtics hit the court against the Philadelphia 76ers as 4.5-point favorites in the season opener for both teams on Wednesday, October 22, 2025 at 7:30 p.m. ET on NBCS-BOS and NBCS-PH. The matchup has an over/under set at 229.5 points.

Celtics vs. 76ers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. 76ers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (86.3%)

Celtics vs. 76ers Betting Trends

• The Celtics went 39-42-1 ATS last season.
• As 4.5-point underdogs or greater, the 76ers went 19-21 against the spread last season.
• A total of 37 Celtics games last season went over the point total.
• Last year, 47 of the 76ers' 82 games went over the point total.
• Boston covered the spread in a lower percentage of its home games than away games last season. Boston covered 18 times in 41 games when playing at home, and it covered 21 times in 41 games when playing on the road.
• Last year, Philadelphia was 12-29-0 at home against the spread (.293 winning percentage). Away, it was 17-24-0 ATS (.415).

Celtics Leaders

• Jayson Tatum averaged 26.8 points, 8.7 rebounds and 6.0 assists last season.
• Derrick White collected 16.4 points, 4.5 rebounds and 4.8 assists. He drained 44.2% of his shots from the floor and 38.4% from beyond the arc, with 3.5 triples per game (fourth in league).
• Jaylen Brown's stats last season included 22.2 points, 5.8 rebounds and 4.5 assists per contest. He sank 46.3% of his shots from the floor and 32.4% from 3-point range, with an average of 1.8 treys.
• Anfernee Simons' numbers last season were 19.3 points, 2.7 rebounds and 4.8 assists per game. He sank 42.6% of his shots from the floor and 36.3% from beyond the arc, with an average of 3.1 treys.
• Payton Pritchard averaged 14.3 points, 3.8 boards and 3.5 assists. He made 47.2% of his shots from the floor and 40.7% from 3-point range, with 3.2 treys per game (10th in NBA).

76ers Leaders

• Tyrese Maxey's numbers last season were 26.3 points, 3.3 boards and 6.1 assists per game, shooting 43.7% from the floor and 33.7% from beyond the arc, with an average of 3.1 made treys.
• Quentin Grimes recorded 14.6 points, 3.0 assists and 4.3 rebounds.
• Kelly Oubre Jr. put up 15.1 points, 6.1 rebounds and 1.8 assists, shooting 47.0% from the field and 29.3% from beyond the arc, with 1.2 made treys per contest.
• Paul George's stats last season were 16.2 points, 5.3 rebounds and 4.3 assists per game, shooting 43.0% from the field and 35.8% from downtown, with an average of 2.3 made treys.
• Trendon Watford recorded 10.5 points, 2.7 assists and 3.7 boards.

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