Cardinals vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 26

Odds updated as of 2:12 p.m.

MLB action on Monday includes the St. Louis Cardinals playing the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Orioles Game Info

• St. Louis Cardinals (30-23) vs. Baltimore Orioles (18-34)
• Date: Monday, May 26, 2025
• Time: 3:05 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and FDSMW

Cardinals vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-118) | BAL: (-100)
• Spread: STL: -1.5 (+146) | BAL: +1.5 (-176)
• Total: 9 -- Over: (-100) | Under: (-122)

Cardinals vs Orioles Probable Starting Pitchers

Probable Pitchers: Erick Fedde (Cardinals) - 3-3, 3.77 ERA vs Charlie Morton (Orioles) - 0-7, 7.68 ERA

The probable starters are Erick Fedde (3-3) for the Cardinals and Charlie Morton (0-7) for the Orioles. Fedde's team is 6-4-0 against the spread in his starts this season. Fedde's team is 0-2 this season when he starts and they're favored on the moneyline. The Orioles did not cover in any of Morton's six starts with a set spread. The Orioles were named the moneyline underdog for two Morton starts this season -- they lost both.

Cardinals vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (53.1%)

Cardinals vs Orioles Moneyline

• St. Louis is the favorite, -118 on the moneyline, while Baltimore is a -100 underdog despite being at home.

Cardinals vs Orioles Spread

• The Orioles are hosting the Cardinals, and are +1.5 on the runline. The Orioles are +146 to cover the spread, and the Cardinals are -176.

Cardinals vs Orioles Over/Under

• An over/under of 9 has been set for Cardinals-Orioles on May 26, with the over being -100 and the under -122.

Bet on St. Louis Cardinals vs. Baltimore Orioles on FanDuel today!

Cardinals vs Orioles Betting Trends

• The Cardinals have come away with 10 wins in the 18 contests they have been listed as the favorites in this season.
• This season St. Louis has come away with a win eight times in 11 chances when named as a favorite of at least -118 on the moneyline.
• The Cardinals and their opponents have hit the over in 27 of their 53 games with a total set by oddsmakers this season.
• In 53 games with a line this season, the Cardinals have a mark of 30-23-0 against the spread.
• The Orioles are 9-14 in games they were listed as the moneyline underdog (winning 39.1% of those games).
• Baltimore has a 5-10 record (winning just 33.3% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Orioles have had an over/under set by bookmakers 52 times, and have combined with opponents to go over the total in 26 of those games (26-24-2).
• The Orioles are 17-35-0 against the spread this season.

Cardinals Player Leaders

• Brendan Donovan leads St. Louis with 65 hits and an OBP of .388, plus a team-best slugging percentage of .460. He's batting .328.
• Among qualifying hitters in MLB, he is sixth in batting average, 14th in on-base percentage, and 52nd in slugging.
• Donovan will look for his third straight game with a hit in this matchup. In his last five games he is hitting .235 with a double and two walks.
• Lars Nootbaar is batting .244 with 10 doubles, seven home runs and 32 walks. He's slugging .398 with an on-base percentage of .350.
• Among qualifiers, he ranks 99th in batting average, 48th in on-base percentage and 101st in slugging percentage.
• Nolan Arenado has collected 44 base hits, an OBP of .306 and a slugging percentage of .378 this season.
• Victor Scott II has two home runs, 19 RBI and a batting average of .277 this season.

Orioles Player Leaders

• Cedric Mullins has nine doubles, 10 home runs and 23 walks while batting .226. He's slugging .446 with an on-base percentage of .320.
• Including all the qualified hitters in MLB, his batting average is 130th, his on-base percentage is 94th, and he is 60th in slugging.
• Ryan O'Hearn's 49 hits, .419 OBP and .537 slugging percentage all lead his team. He has a batting average of .329.
• His batting average is fifth among all qualified players, his on-base percentage is fifth, and he is 15th in slugging.
• Adley Rutschman is hitting .211 with seven doubles, a triple, five home runs and 24 walks.
• Gunnar Henderson has 10 doubles, two triples, seven home runs and 16 walks while hitting .265.

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