Canucks vs Penguins NHL Prediction, Odds, Picks, Best Bets for Oct. 21

The NHL slate on Tuesday includes the Vancouver Canucks facing the Pittsburgh Penguins.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NHL betting odds.

Canucks vs Penguins Game Info

• Vancouver Canucks (4-2) vs. Pittsburgh Penguins (4-2)
• Date: Tuesday, October 21, 2025
• Time: 7 p.m. ET
• Venue: PPG Paints Arena -- Pittsburgh, Pennsylvania
• Coverage: ESPN+

Canucks vs Penguins Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Canucks vs Penguins Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Canucks win (53.6%)

Canucks vs Penguins Puck Line

• The Canucks are favored by 1.5 goals. The Canucks are +194 to cover the spread, with the Penguins being -245.

Canucks vs Penguins Over/Under

• The over/under for Canucks-Penguins on Oct. 21 is 6.5. The over is +112, and the under is -140.

Canucks vs Penguins Moneyline

• Pittsburgh is a +100 underdog on the moneyline, while Vancouver is a -120 favorite on the road.

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