Canadiens vs Flames NHL Prediction, Odds, Picks, Best Bets for Oct. 22

The Montreal Canadiens are among the NHL squads busy on Wednesday, versus the Calgary Flames.

We've got you covered, in terms of the vital info regarding NHL betting lines, before you make your wager on FanDuel Sportsbook.

Canadiens vs Flames Game Info

• Montreal Canadiens (5-2) vs. Calgary Flames (1-6)
• Date: Wednesday, October 22, 2025
• Time: 8:30 p.m. ET
• Venue: Scotiabank Saddledome -- Calgary, Alberta
• Coverage: ESPN+

Canadiens vs Flames Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Canadiens vs Flames Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Flames win (51.9%)

Canadiens vs Flames Puck Line

• The Canadiens are favored by 1.5 goals against the Flames. The Canadiens are +186 to cover the spread, while the Flames are -235.

Canadiens vs Flames Over/Under

• The over/under for the Canadiens versus Flames matchup on Oct. 22 has been set at 5.5, with -134 odds on the over and +110 odds on the under.

Canadiens vs Flames Moneyline

• Montreal is the favorite, -128 on the moneyline, while Calgary is a +106 underdog despite being at home.

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