Bulls vs. Pistons Prediction, Odds, Picks, Best Bets for Oct. 22

Bulls vs. Pistons Game Info

• Date: Wednesday, October 22, 2025
• Time: 8 p.m. ET
• Venue: United Center -- Chicago, Illinois
• Coverage: CHSN and FDSDET

The Detroit Pistons square off against the Chicago Bulls as just 3-point favorites in the season opener for both teams on Wednesday, October 22, 2025 at 8 p.m. ET on CHSN and FDSDET. The over/under is set at 236.5 for the matchup.

Bulls vs. Pistons Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Bulls vs. Pistons Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Pistons win (53.9%)

Bulls vs. Pistons Betting Trends

• The Pistons compiled a 42-36-4 record against the spread last season.
• Against the spread, as underdogs of 3 points or more, the Bulls went 25-24-2 last year.
• Last season, the combined scoring went over the point total 42 times in Pistons games.
• Out of 82 Bulls games last season, 44 went over the total.
• When playing at home last season, Detroit owned a worse record against the spread (19-20-2) compared to its ATS record in road games (23-16-2).
• Against the spread last year, Chicago had better results away (22-17-2) than at home (21-19-1).

Pistons Leaders

• Cade Cunningham put up 26.1 points last year, plus 6.1 boards and 9.1 assists.
• Jalen Duren put up 11.8 points, 10.3 rebounds and 2.7 assists. He made 69.2% of his shots from the field (second in league).
• Tobias Harris' stats last season included 13.7 points, 5.9 boards and 2.2 assists per contest. He drained 47.7% of his shots from the field and 34.5% from 3-point range, with an average of 1.2 triples.
• Caris LeVert put up 12.1 points, 3.2 boards and 3.4 assists. He drained 46.7% of his shots from the floor and 37.3% from 3-point range, with 1.7 triples per contest.
• Ausar Thompson recorded 10.1 points, 5.1 boards and 2.3 assists per game, plus 1.7 steals (fourth in league) and 0.7 blocks.

Bulls Leaders

• Nikola Vucevic's numbers last season were 18.5 points, 10.1 boards and 3.5 assists per contest, shooting 53% from the field and 40.2% from downtown, with an average of 1.8 made 3-pointers.
• Josh Giddey recorded 14.6 points, 8.1 rebounds and 7.2 assists last year, shooting 46.5% from the field and 37.8% from downtown, with 1.5 made treys per contest.
• Coby White averaged 20.4 points, 4.5 assists and 3.7 rebounds.
• Matas Buzelis collected 8.6 points, 1 assists and 3.5 boards.
• Kevin Huerter collected 9.9 points, 3 rebounds and 2.3 assists, shooting 42.5% from the floor and 33.8% from downtown, with 1.9 made 3-pointers per game.

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