Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 6:12 p.m.

The MLB schedule on Tuesday includes the Milwaukee Brewers facing the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Brewers vs Pirates Game Info

• Milwaukee Brewers (93-57) vs. Pittsburgh Pirates (75-75)
• Date: Tuesday, September 15, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Brewers.TV

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-215) | PIT: (+180)
• Spread: MIL: -1.5 (-122) | PIT: +1.5 (+102)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 14-5, 1.95 ERA vs Lake Bachar (Pirates) - 1-3, 3.52 ERA

The probable starters are Jacob Misiorowski (14-5) for the Brewers and Lake Bachar (1-3) for the Pirates. Misiorowski's team is 16-11-0 against the spread in his starts this season. Misiorowski's team is 18-6 this season when he starts and they are the moneyline favorite. The Pirates have gone 7-2-0 ATS in Bachar's nine starts with a set spread. The Pirates have a 5-2 record in Bachar's seven starts this season when they were the underdog on the moneyline.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (55.3%)

Brewers vs Pirates Moneyline

• Pittsburgh is the underdog, +180 on the moneyline, while Milwaukee is a -215 favorite despite being on the road.

Brewers vs Pirates Spread

• The Brewers are at the Pirates and are favored by 1.5 runs (-122 to cover) on the runline. Pittsburgh is +102 to cover.

Brewers vs Pirates Over/Under

• The over/under for the Brewers versus Pirates contest on Sept. 15 has been set at 7.5, with -110 odds on the over and -110 odds on the under.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have come away with 74 wins in the 116 contests they have been listed as the favorites in this season.
• Milwaukee has a record of 9-1 in contests when sportsbooks favor them by -215 or more on the moneyline.
• Contests with the Brewers have gone over the total set by bookmakers in 65 of 149 chances this season.
• The Brewers are 78-71-0 against the spread in their 149 games with a line set by sportsbooks this season.
• The Pirates have a 31-39 record in games they were the underdog on the moneyline (winning 44.3% of those games).
• Pittsburgh has played in four games as a moneyline underdog with odds of +180 or longer without earning a win.
• The Pirates have played in 148 games with an over/under set, and have combined with their opponents to go over the total 77 times (77-67-4).
• The Pirates have covered 48.6% of their games this season, going 72-76-0 ATS.

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.445) thanks to 55 extra-base hits. He has a .267 batting average and an on-base percentage of .365.
• Among all qualifying batters in baseball, his batting average ranks 52nd, his on-base percentage ranks 23rd, and he is 50th in slugging.
• Turang will look for his fourth straight game with a hit in this contest. In his last five games he is hitting .588 with two doubles, two home runs, five walks and seven RBIs.
• William Contreras has an OPS of .764, fueled by an OBP of .343 and a team-best slugging percentage of .420 this season. He's batting .273.
• Among qualified hitters, he is 34th in batting average, 49th in on-base percentage and 74th in slugging percentage.
• Contreras has picked up at least one hit in four straight games. During his last five outings he is batting .316 with three home runs, four walks and 12 RBIs.
• Jake Bauers leads his team in OBP (.394) and total hits (119) this season.
• Bauers brings a three-game hitting streak into this game. During his last five outings he is hitting .250 with two home runs, two walks and five RBIs.
• Jackson Chourio has 23 home runs, 67 RBI and a batting average of .292 this season.

Pirates Player Leaders

• Bryan Reynolds has accumulated an on-base percentage of .370, a team-best for the Pirates. He's batting .266 and slugging .429.
• Including all the qualifying hitters in the big leagues, his batting average places him 56th, his on-base percentage is 16th, and he is 65th in slugging.
• Reynolds hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .200 with a home run, two walks and two RBIs.
• Brandon Lowe has 140 hits to pace his team. He has a batting average of .258 while slugging .474 with an on-base percentage of .327.
• He is currently 66th in batting average, 74th in on-base percentage and 28th in slugging percentage among all qualifying hitters.
• Nick Gonzales has a .393 slugging percentage, which leads the Pirates.
• Ryan O'Hearn is batting .266 with 15 doubles, 18 home runs and 31 walks.

Brewers vs Pirates Head to Head

• 8/6/2026: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/5/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/4/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 8/3/2026: 4-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +136)
• 7/12/2026: 14-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2026: 3-2 PIT (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2026: 7-6 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2026: 5-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/25/2026: 6-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/24/2026: 6-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!