Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 6:12 p.m.

The MLB's Tuesday slate includes the Cleveland Guardians facing the Chicago White Sox.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs White Sox Game Info

• Cleveland Guardians (76-75) vs. Chicago White Sox (77-73)
• Date: Tuesday, September 15, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-152) | CHW: (+128)
• Spread: CLE: -1.5 (+140) | CHW: +1.5 (-170)
• Total: 8.5 -- Over: (-122) | Under: (+100)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Foster Griffin (Guardians) - 15-5, 3.65 ERA vs Chris Murphy (White Sox) - 3-0, 3.94 ERA

The probable pitchers are Foster Griffin (15-5) for the Guardians and Chris Murphy (3-0) for the White Sox. Griffin and his team are 17-10-0 ATS this season when he starts. When Griffin starts a game and his team is the favorite on the moneyline, they have a record of 7-3. Murphy has started just one game with a set spread, which the White Sox covered. The White Sox were named the moneyline underdog for one Murphy start this season -- they lost.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.6%)

Guardians vs White Sox Moneyline

• Looking at the moneyline for Guardians-White Sox, Cleveland is the favorite at -152, and Chicago is +128 playing on the road.

Guardians vs White Sox Spread

• The White Sox are at the Guardians, and are +1.5 on the runline. The White Sox are +140 to cover the spread, and the Guardians are -170.

Guardians vs White Sox Over/Under

• A total of 8.5 runs has been set for the Guardians-White Sox contest on Sept. 15, with the over available at -122 and the under at +100.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been victorious in 43, or 50.6%, of the 85 contests they have been chosen as favorites in this season.
• This season Cleveland has been victorious 16 times in 25 chances when named as a favorite of at least -152 on the moneyline.
• Contests with the Guardians have gone over the total set by bookmakers in 70 of 143 chances this season.
• The Guardians have an against the spread record of 67-76-0 in 143 games with a line this season.
• The White Sox are 50-53 in games they were listed as the moneyline underdog (winning 48.5% of those games).
• Chicago has gone 14-20 when it has played as a moneyline underdog with odds of +128 or longer (41.2%).
• The White Sox have combined with opponents to go over the total 81 times this season for an 81-65-1 record against the over/under.
• The White Sox have put together an 82-65-0 record against the spread this season (covering 55.8% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 134 hits, batting .289 this season with 45 extra-base hits. He has an on-base percentage of .362 and a slugging percentage of .453.
• Among qualified hitters in MLB, he is 13th in batting average, 26th in on-base percentage, and 44th in slugging.
• Steven Kwan has a slash line of .278/.375/.346 this season and a team-best OPS of .721.
• Among qualified hitters, he is 28th in batting average, 10th in on-base percentage and 130th in slugging percentage.
• Kwan has picked up at least one hit in eight games in a row. During his last 10 games he is batting .350 with four doubles, a home run, five walks and three RBIs.
• Jose Ramirez has 99 hits this season and has a slash line of .230/.320/.362.
• Brayan Rocchio has 13 home runs, 65 RBI and a batting average of .247 this season.
• Rocchio heads into this game on a two-game hitting streak. During his last five outings he is batting .176 with a double, a walk and three RBIs.

White Sox Player Leaders

• Miguel Vargas is leading the White Sox with 137 hits. He's batting .249 and slugging .475 with an on-base percentage of .357.
• Including all the qualified hitters in the big leagues, his batting average ranks 79th, his on-base percentage ranks 36th, and he is 27th in slugging.
• Vargas hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .238 with a home run, two walks and two RBIs.
• Sam Antonacci's .366 on-base percentage paces his team. He has a batting average of .269 while slugging .392.
• His batting average is 41st among all qualified players, his on-base percentage ranks 21st, and he is 98th in slugging.
• Chase Meidroth has a team-best .397 slugging percentage.
• Tristan Peters is hitting .277 with 31 doubles, four triples, 12 home runs and 35 walks.

Guardians vs White Sox Head to Head

• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/23/2026: 2-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/22/2026: 6-5 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!