Brewers vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for NLDS Game 1 on Oct. 4

Odds updated as of 1:11 p.m.

The MLB schedule on Saturday includes the Milwaukee Brewers taking on the Chicago Cubs in Game 1 of the NLDS.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Brewers vs Cubs Game Info

• Milwaukee Brewers (97-65) vs. Chicago Cubs (92-70)
• Date: Saturday, October 4, 2025
• Time: 2:08 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: TBS and HBO Max

Brewers vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-136) | CHC: (+116)
• Spread: MIL: -1.5 (+164) | CHC: +1.5 (-200)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Brewers vs Cubs Probable Starting Pitchers

Probable Pitchers: Freddy Peralta (Brewers) - 17-6, 2.70 ERA vs Matthew Boyd (Cubs) - 14-8, 3.21 ERA

The probable pitchers are Freddy Peralta (17-6, 2.70 ERA) for the Brewers and Matthew Boyd (14-8, 3.21 ERA) for the Cubs. Peralta and his team are 19-14-0 ATS this season when he starts. Peralta's team has been victorious in 63.6% of the games he's started as the moneyline favorite with a record of 14-8. The Cubs have a 14-17-0 ATS record in Boyd's 31 starts that had a set spread. The Cubs are 1-4 in Boyd's five starts this season that they were the underdog on the moneyline.

Brewers vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (57.4%)

Brewers vs Cubs Moneyline

• Looking at the moneyline for Cubs-Brewers, Chicago is the underdog at +116, and Milwaukee is -136 playing at home.

Brewers vs Cubs Spread

• The Cubs are +1.5 on the spread (-200 to cover), and Milwaukee is +164 to cover the runline.

Brewers vs Cubs Over/Under

• Brewers versus Cubs on Oct. 4 has an over/under of 7.5 runs, with the odds on the over -110 and the under set at -110.

Bet on Milwaukee Brewers vs. Chicago Cubs on FanDuel today!

Brewers vs Cubs Betting Trends

• The Brewers have been favorites in 96 games this season and have come away with the win 60 times (62.5%) in those contests.
• Milwaukee has a record of 39-14 when favored by -136 or more this year.
• The Brewers and their opponents have gone over the total this season in 79 of their 159 opportunities.
• The Brewers are 87-72-0 against the spread in their 159 games with a line set by sportsbooks this season.
• The Cubs have gone 18-26 in games they were listed as the moneyline underdog (winning 40.9% of those games).
• Chicago is 5-9 (winning only 35.7% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Cubs have combined with opponents to go over the total 74 times this season for a 74-75-11 record against the over/under.
• The Cubs have covered 48.1% of their games this season, going 77-83-0 ATS.

Brewers Player Leaders

• Brice Turang leads Milwaukee OPS (.794) this season. He has a .288 batting average, an on-base percentage of .359, and a slugging percentage of .435.
• Among all qualified batters in MLB, he ranks 16th in batting average, 20th in on-base percentage, and 71st in slugging.
• Turang will look for his fifth straight game with a hit in this matchup. During his last five outings he is hitting .353 with two doubles, four walks and four RBIs.
• Christian Yelich has 21 doubles, 29 home runs and 64 walks. He's batting .264 and slugging .452 with an on-base percentage of .343.
• Among qualifiers, he ranks 51st in batting average, 49th in on-base percentage and 56th in slugging percentage.
• William Contreras has 147 hits this season and has a slash line of .260/.355/.399.
• Jackson Chourio leads Milwaukee in total hits (148) this season while batting .270 with 60 extra-base hits.
• Chourio takes a two-game hitting streak into this game. In his last five games he is batting .200 with a double, a home run, two walks and an RBI.

Cubs Player Leaders

• Kyle Tucker has racked up an on-base percentage of .377, a team-high for the Cubs. He's batting .266 and slugging .464.
• He is 46th in batting average, seventh in on-base percentage and 44th in slugging percentage among all qualifying hitters in the big leagues.
• Nico Hoerner's .394 slugging percentage paces his team. He has a batting average of .297 with an on-base percentage of .345.
• He is eighth in batting average, 46th in on-base percentage and 110th in slugging percentage in the majors.
• Pete Crow-Armstrong has 37 doubles, four triples, 31 home runs and 29 walks while batting .247.
• Michael Busch has 137 hits to pace his team.

Brewers vs Cubs Head to Head

• 8/21/2025: 4-1 MIL (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/20/2025: 4-3 CHC (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/19/2025: 4-1 CHC (Favorite: Brewers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/19/2025: 6-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/18/2025: 7-0 MIL (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/30/2025: 10-3 CHC (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/29/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/28/2025: 8-4 MIL (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/19/2025: 8-7 MIL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/17/2025: 5-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!