Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 2:13 p.m.

The Milwaukee Brewers versus the St. Louis Cardinals is on the MLB schedule for Sunday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (102-59) vs. St. Louis Cardinals (77-84)
• Date: Sunday, September 27, 2026
• Time: 3:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-205) | STL: (+172)
• Spread: MIL: -1.5 (+114) | STL: +1.5 (-137)
• Total: 7.5 -- Over: (+104) | Under: (-128)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 15-5, 1.86 ERA vs Andre Pallante (Cardinals) - 12-8, 3.61 ERA

The probable starters are Jacob Misiorowski (15-5) for the Brewers and Andre Pallante (12-8) for the Cardinals. Misiorowski and his team are 18-11-0 ATS this season when he starts. Misiorowski's team has been victorious in 76.9% of the games he's started as the moneyline favorite with a record of 20-6. The Cardinals have a 14-13-0 ATS record in Pallante's 27 starts that had a set spread. The Cardinals are 9-5 in Pallante's 14 starts this season that they were the moneyline underdog.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (65%)

Brewers vs Cardinals Moneyline

• Milwaukee is the favorite, -205 on the moneyline, while St. Louis is a +172 underdog on the road.

Brewers vs Cardinals Spread

• The Brewers are favored by 1.5 runs at home versus the Cardinals. The Brewers are +114 to cover the spread, while the Cardinals are -137.

Brewers vs Cardinals Over/Under

• The over/under for the Brewers versus Cardinals contest on Sept. 27 has been set at 7.5, with +104 odds on the over and -128 odds on the under.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have been favorites in 124 games this season and have come away with the win 81 times (65.3%) in those contests.
• Milwaukee has a record of 15-5 when favored by -205 or more this year.
• The Brewers and their opponents have gone over in 70 of their 160 games with a total set by sportsbooks this season.
• The Brewers have posted a record of 83-77-0 against the spread this season.
• The Cardinals have won 45.1% of the games this season they were the moneyline underdog (46-56).
• St. Louis has a 3-6 record (winning just 33.3% of its games) when it has played as a moneyline underdog of +172 or longer.
• The Cardinals have played in 157 games with a set over/under, and have combined with opponents to go over the total 72 times (72-78-7).
• The Cardinals have collected an 84-73-0 record against the spread this season (covering 53.5% of the time).

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.453) thanks to 61 extra-base hits. He has a .270 batting average and an on-base percentage of .368.
• He is 41st in batting average, 17th in on-base percentage, and 45th in slugging among all qualifying hitters in the majors.
• Turang will look for his sixth straight game with a hit in this matchup. In his last five games he is batting .381 with three doubles, two home runs, a walk and six RBIs.
• William Contreras has 27 doubles, a triple, 18 home runs and 61 walks. He's batting .270 and slugging .417 with an on-base percentage of .341.
• He is 41st in batting average, 53rd in on-base percentage and 76th in slugging among qualified hitters.
• Contreras has picked up at least one hit in two games in a row. In his last five games he is batting .235 with two walks and six RBIs.
• Jake Bauers has 126 hits and an OBP of .390, both of which lead the Brewers this season.
• Jackson Chourio has 25 home runs, 73 RBI and a batting average of .288 this season.
• Chourio enters this matchup on a four-game hitting streak. During his last five outings he is batting .385 with a home run, three walks and three RBIs.

Cardinals Player Leaders

• Alec Burleson has racked up a slugging percentage of .473 and has 169 hits, both team-best numbers for the Cardinals. He's batting .279 and with an on-base percentage of .343.
• Including all qualified hitters in the majors, he ranks 27th in batting average, 51st in on-base percentage and 31st in slugging percentage.
• Burleson hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .211 with three home runs and five RBIs.
• Jordan Walker is hitting .271 with 33 doubles, 29 home runs and 50 walks. He's slugging .469 with an on-base percentage of .329.
• He is 40th in batting average, 73rd in on-base percentage and 34th in slugging percentage in MLB.
• Ivan Herrera has an on-base percentage of .353, a team-high for the Cardinals.
• JJ Wetherholt has 15 doubles, 17 home runs and 64 walks while batting .242.

Brewers vs Cardinals Head to Head

• 9/26/2026: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/25/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/9/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/8/2026: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/7/2026: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/7/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/6/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/27/2026: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/26/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/25/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)

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