Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 9:12 p.m.

The Sunday slate in MLB includes a matchup between the Milwaukee Brewers and the St. Louis Cardinals.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (101-59) vs. St. Louis Cardinals (77-83)
• Date: Sunday, September 27, 2026
• Time: 3:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-250) | STL: (+205)
• Spread: MIL: -1.5 (-110) | STL: +1.5 (-110)
• Total: 7.5 -- Over: (+118) | Under: (-144)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 15-5, 1.86 ERA vs Andre Pallante (Cardinals) - 12-8, 3.61 ERA

The probable starters are Jacob Misiorowski (15-5) for the Brewers and Andre Pallante (12-8) for the Cardinals. Misiorowski's team is 18-11-0 against the spread in his starts this season. Misiorowski's team has a record of 20-6 this season when he starts and they are the favorite on the moneyline. The Cardinals have a 14-13-0 record against the spread in Pallante's starts. The Cardinals have a 9-5 record in Pallante's 14 starts this season when they were the underdog on the moneyline.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (65.7%)

Brewers vs Cardinals Moneyline

• St. Louis is a +205 underdog on the moneyline, while Milwaukee is a -250 favorite at home.

Brewers vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Brewers. The Cardinals are -110 to cover the spread, and the Brewers are -110.

Brewers vs Cardinals Over/Under

• An over/under of 7.5 has been set for Brewers-Cardinals on Sept. 27, with the over being +118 and the under -144.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have been chosen as favorites in 123 games this year and have walked away with the win 80 times (65%) in those games.
• This year Milwaukee has won five of six games when listed as at least -250 on the moneyline.
• The Brewers and their opponents have gone over the total this season in 70 of their 159 opportunities.
• The Brewers have an against the spread record of 83-76-0 in 159 games with a line this season.
• The Cardinals have won 46 of the 101 games they were listed as the moneyline underdog this season (45.5%).
• St. Louis is 2-2 (winning 50% of its games) when it has played as a moneyline underdog of +205 or longer.
• The Cardinals have combined with opponents to go over the total 72 times this season for a 72-77-7 record against the over/under.
• The Cardinals have covered 53.2% of their games this season, going 83-73-0 ATS.

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.449) thanks to 60 extra-base hits. He has a .270 batting average and an on-base percentage of .367.
• Among qualifying hitters in the majors, his batting average ranks 41st, his on-base percentage ranks 19th, and he is 46th in slugging.
• Turang will look for his fifth straight game with a hit in this contest. During his last five outings he is batting .318 with three doubles, a home run and four RBIs.
• William Contreras is batting .270 with 27 doubles, a triple, 18 home runs and 60 walks, while slugging .417 with an on-base percentage of .340.
• He ranks 41st in batting average, 54th in on-base percentage and 77th in slugging among qualifying batters.
• Jake Bauers has 126 hits and an OBP of .391, both of which lead the Brewers this season.
• Bauers has picked up a hit in two games in a row. During his last five outings he is batting .263 with two doubles, two walks and three RBIs.
• Jackson Chourio is batting .286 with a .347 OBP and 72 RBI for Milwaukee this season.
• Chourio has safely hit in three straight games. In his last five games he is batting .333 with a home run, four walks and two RBIs.

Cardinals Player Leaders

• Alec Burleson has put up a slugging percentage of .469, a team-best for the Cardinals. He's batting .280 with an on-base percentage of .344.
• Including all qualified hitters, he ranks 23rd in batting average, while his on-base percentage ranks 49th and he is 34th in slugging.
• Burleson heads into this matchup on a three-game hitting streak. During his last five outings he is batting .158 with two home runs and four RBIs.
• Jordan Walker's 163 hits lead his team. He has a batting average of .271 while slugging .471 with an on-base percentage of .329.
• Including all qualifying hitters, his batting average puts him 40th, his on-base percentage ranks 70th, and he is 33rd in slugging.
• Ivan Herrera a has .355 on-base percentage to pace the Cardinals.
• JJ Wetherholt is batting .244 with 15 doubles, 17 home runs and 64 walks.

Brewers vs Cardinals Head to Head

• 9/25/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/9/2026: 8-4 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/8/2026: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/7/2026: 10-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/7/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/6/2026: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/27/2026: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/26/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/25/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/6/2026: 6-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!