Blue Jays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 1:12 a.m.

Wednesday's slate in the MLB includes a matchup between the Toronto Blue Jays and the Cleveland Guardians.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Guardians Game Info

• Toronto Blue Jays (68-71) vs. Cleveland Guardians (70-68)
• Date: Wednesday, September 2, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and SNET

Blue Jays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-134) | CLE: (+114)
• Spread: TOR: -1.5 (+134) | CLE: +1.5 (-162)
• Total: 7 -- Over: (-115) | Under: (-105)

Blue Jays vs Guardians Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Blue Jays) - 9-5, 2.33 ERA vs Joey Cantillo (Guardians) - 9-7, 3.70 ERA

This contest's pitching matchup is set, as the Blue Jays will send Dylan Cease (9-5) to the mound, while Joey Cantillo (9-7) will get the nod for the Guardians. Cease's team is 15-10-0 against the spread this season in his starts. Cease's team has won 61.9% of his starts when they are favored on the moneyline (13-8). The Guardians have a 17-11-0 record against the spread in Cantillo's starts. The Guardians have been the moneyline underdog in 13 of Cantillo's starts this season, and they went 9-4 in those games.

Blue Jays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (50.2%)

Blue Jays vs Guardians Moneyline

• Toronto is a -134 favorite on the moneyline, while Cleveland is a +114 underdog at home.

Blue Jays vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Blue Jays. The Guardians are -162 to cover the spread, and the Blue Jays are +134.

Blue Jays vs Guardians Over/Under

• The over/under for the Blue Jays versus Guardians game on Sept. 2 has been set at 7, with -115 odds on the over and -105 odds on the under.

Bet on Toronto Blue Jays vs. Cleveland Guardians on FanDuel today!

Blue Jays vs Guardians Betting Trends

• The Blue Jays have won in 36, or 54.5%, of the 66 contests they have been named as odds-on favorites in this year.
• This season Toronto has come away with a win 19 times in 35 chances when named as a favorite of at least -134 on the moneyline.
• The Blue Jays and their opponents have gone over the total this season in 68 of their 135 opportunities.
• The Blue Jays are 66-69-0 against the spread in their 135 games with a line set by sportsbooks this season.
• The Guardians are 26-25 in games they were listed as the moneyline underdog (winning 51% of those games).
• In games it has played as a moneyline underdog with odds of +114 or longer, Cleveland has a 16-11 record (winning 59.3% of its games).
• In the 132 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 63 times (63-69-0).
• The Guardians have gone 64-68-0 against the spread this season.

Blue Jays Player Leaders

• Ernie Clement has an OPS of .690, fueled by an OBP of .301 and a team-best slugging percentage of .389 this season. He has a .275 batting average.
• Among all qualified hitters in baseball, he ranks 33rd in batting average, 118th in on-base percentage, and 103rd in slugging.
• Vladimir Guerrero Jr. has 120 hits this season and a team-best OBP of .330. He's batting .258 and slugging .348.
• Among all qualifying players, he ranks 63rd in batting average, 73rd in on-base percentage and 133rd in slugging percentage.
• Guerrero heads into this game looking to extend his two-game hit streak. During his last five outings he is batting .158 with a double, two walks and two RBIs.
• Kazuma Okamoto leads Toronto in total hits (112) this season, and 49 of those have gone for extra bases.
• Okamoto takes a two-game hitting streak into this game. In his last five games he is hitting .267 with a double, two home runs, three walks and four RBIs.
• George Springer has 14 home runs, 45 RBI and a batting average of .251 this season.

Guardians Player Leaders

• Chase DeLauter has accumulated a slugging percentage of .450 and has 125 hits, both team-best numbers for the Guardians. He's batting .290 and with an on-base percentage of .362.
• Including all the qualifying hitters in the big leagues, his batting average places him 10th, his on-base percentage ranks 27th, and he is 44th in slugging.
• Jose Ramirez is hitting .244 with 24 doubles, 11 home runs and 56 walks. He's slugging .391 with an on-base percentage of .338.
• Including all qualifying hitters, he is 91st in batting average, 58th in on-base percentage and 100th in slugging percentage.
• Steven Kwan a has .376 on-base percentage to pace the Guardians.
• Brayan Rocchio is hitting .246 with 19 doubles, two triples, 10 home runs and 32 walks.

Blue Jays vs Guardians Head to Head

• 9/1/2026: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/26/2026: 4-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/25/2026: 5-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/24/2026: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/26/2025: 6-0 TOR (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/25/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/24/2025: 10-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/4/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/3/2025: 5-3 CLE (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/2/2025: 5-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!