Baker Mayfield Fantasy Football Week 6: Stats and Projections vs. 49ers

In Week 6 (Sunday at 4:25 p.m. ET), quarterback Baker Mayfield and the Tampa Bay Buccaneers will meet the San Francisco 49ers, who have the 14th-ranked pass defense in the NFL (207.6 yards conceded per game).

For more details on Mayfield, if you're thinking about him for your daily fantasy lineup, check out this article before his upcoming matchup versus the 49ers.

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Baker Mayfield Week 6 Fantasy Football Projection

• Matchup: Tampa Bay Buccaneers vs. San Francisco 49ers
• Game Date: October 12, 2025
• Game Time: 4:25 p.m.
• Projected Fantasy Points: 19.2
• Projected Passing Yards: 256.10
• Projected Passing TDs: 2.08
• Projected Rushing Yards: 17.83
• Projected Rushing TDs: 0.15

Projections provided by numberFire

Mayfield Fantasy Performance

• Mayfield has been one of the best players in fantasy at the QB position this season, ranking fourth with 21.2 fantasy points per game (105.8 total points). He is fourth in fantasy points among all players.
• Over his last three games, Mayfield has tallied 63.3 fantasy points (21.1 per game), as he's amassed 901 yards on 70-of-102 passing with five touchdowns and one pick. As a runner, he's tacked on 72 rushing yards on 11 carries.
• The peak of Mayfield's fantasy season was last week's outburst against the Seattle Seahawks, a matchup in which he posted 26.7 fantasy points -- 29-of-33 (87.9%), 379 yards, 2 TDs, 0 INTs.
• From a fantasy standpoint, Baker Mayfield delivered his worst fantasy-point total of the campaign (17.7 points) in Week 3 against the New York Jets, throwing for 233 yards and one touchdown with zero picks.

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49ers Defensive Performance

• San Francisco has conceded over 300 yards passing to just one player this year.
• The 49ers have allowed four players to pass for at least one TD in a game this season.
• A total of two players have thrown for two or more touchdowns against San Francisco this year.
• The 49ers have allowed at least three passing TDs to two opposing QBs this year.
• A total of one player has recorded more than 100 yards receiving in a game versus San Francisco this year.
• A total of Seven players have hauled in a TD pass versus the 49ers this year.
• Just one player has caught more than one TD pass versus San Francisco this season.
• The 49ers have allowed only one player to pile up over 100 yards rushing in a game this year.
• A total of two players have rushed for at least one TD against San Francisco this season.
• The 49ers have not allowed an opposing player to score two or more rushing TDs against them this season.

Want more data and analysis on Baker Mayfield? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.