Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 9:11 p.m.

The Houston Astros are among the MLB squads playing on Thursday, up against the Athletics.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Athletics Game Info

• Houston Astros (78-80) vs. Athletics (63-95)
• Date: Thursday, September 24, 2026
• Time: 9:40 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-178) | OAK: (+150)
• Spread: HOU: -1.5 (-118) | OAK: +1.5 (-102)
• Total: 10.5 -- Over: (-122) | Under: (+100)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Peter Lambert (Astros) - 8-10, 3.70 ERA vs Mason Barnett (Athletics) - 1-4, 7.16 ERA

The Astros will give the ball to Peter Lambert (8-10, 3.70 ERA), who is eyeing win No. 9 on the season, and the Athletics will counter with Mason Barnett (1-4, 7.16 ERA). Lambert and his team have a record of 16-11-0 against the spread when he starts. Lambert's team is 7-5 this season when he starts and they are the moneyline favorite. The Athletics are 2-3-0 against the spread when Barnett starts. The Athletics were the moneyline underdog for five Barnett starts this season -- they lost each time.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.2%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -178 favorite, while the Athletics are a +150 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -118 to cover, while the Athletics are -102 to cover.

Astros vs Athletics Over/Under

• The over/under for the Astros versus Athletics game on Sept. 24 has been set at 10.5, with -122 odds on the over and +100 odds on the under.

Bet on Houston Astros vs. Athletics on FanDuel today!

Astros vs Athletics Betting Trends

• The Astros have won in 35, or 51.5%, of the 68 contests they have been named as odds-on favorites in this year.
• This season, the Astros have come away with a win one time in six chances when named as a favorite of at least -178 or shorter on the moneyline.
• The Astros and their opponents have hit the over in 77 of their 158 games with a total this season.
• The Astros have an against the spread record of 79-79-0 in 158 games with a line this season.
• The Athletics have won 46 of the 119 games they were the moneyline underdog this season (38.7%).
• When playing as a moneyline underdog with odds of +150 or longer, the Athletics have a record of 10-22 (31.2%).
• The Athletics have played in 157 games with a set over/under, and have combined with their opponents to go over the total 82 times (82-73-2).
• The Athletics have gone 75-82-0 ATS this season.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.432), slugging percentage (.603) and total hits (174) this season. He has a .316 batting average.
• Among qualifying hitters, he ranks first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Alvarez has recorded a base hit in eight games in a row. During his last 10 outings he is hitting .375 with three doubles, three home runs, eight walks and six RBIs.
• Isaac Paredes has 27 doubles, a triple, 23 home runs and 68 walks. He's batting .261 and slugging .441 with an on-base percentage of .359.
• Among all qualifying hitters, he ranks 62nd in batting average, 31st in on-base percentage and 53rd in slugging percentage.
• Paredes takes a two-game streak with at least one hit into this contest. During his last five outings he is hitting .389 with a double, two home runs, three walks and six RBIs.
• Christian Walker has collected 123 base hits, an OBP of .293 and a slugging percentage of .409 this season.
• Walker brings a two-game hitting streak into this matchup. In his last five games he is hitting .200 with a home run, a walk and three RBIs.
• Jose Altuve has 16 home runs, 46 RBI and a batting average of .252 this season.
• Altuve has hit safely in seven straight games. In his last 10 games he is hitting .317 with two doubles, a home run, a walk and two RBIs.

Athletics Player Leaders

• Jeff McNeil has accumulated a slugging percentage of .364, a team-high for the Athletics. He's batting .265 with an on-base percentage of .314.
• Including all the qualifying players in MLB, his batting average puts him 49th, his on-base percentage ranks 97th, and he is 120th in slugging.
• Shea Langeliers has 21 doubles, 23 home runs and 35 walks while hitting .266. He's slugging .485 with an on-base percentage of .330.
• Zack Gelof is hitting .256 with 16 doubles, two triples, 20 home runs and 30 walks.
• Lawrence Butler leads his team with 107 hits and a .325 OBP.

Astros vs Athletics Head to Head

• 8/23/2026: 7-6 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 8/22/2026: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +215)
• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/25/2025: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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