Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 4:11 a.m.

Thursday's slate in the MLB includes a matchup between the Houston Astros and the Athletics.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Astros vs Athletics Game Info

• Houston Astros (78-80) vs. Athletics (63-95)
• Date: Thursday, September 24, 2026
• Time: 9:40 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | OAK: (+136)
• Spread: HOU: -1.5 (-106) | OAK: +1.5 (-113)
• Total: 10.5 -- Over: (-140) | Under: (+114)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Peter Lambert (Astros) - 8-10, 3.70 ERA vs Mason Barnett (Athletics) - 1-4, 7.16 ERA

The Astros will look to Peter Lambert (8-10) against the Athletics and Mason Barnett (1-4). When Lambert starts, his team is 16-11-0 against the spread this season. Lambert's team has a record of 7-5 this season when he starts and they are the favorite on the moneyline. The Athletics have a 2-3-0 ATS record in Barnett's five starts that had a set spread. The Athletics were the moneyline underdog for five Barnett starts this season -- they lost every game.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (52.3%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -162 favorite, while the Athletics are a +136 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -106 to cover, while the Athletics are -113 to cover.

Astros vs Athletics Over/Under

• Astros versus Athletics on Sept. 24 has an over/under of 10.5 runs, with the odds on the over -140 and the under set at +114.

Bet on Houston Astros vs. Athletics on FanDuel today!

Astros vs Athletics Betting Trends

• The Astros have been chosen as favorites in 68 games this year and have walked away with the win 35 times (51.5%) in those games.
• This season, the Astros have come away with a win seven times in 17 chances when named as a favorite of at least -162 or better on the moneyline.
• The Astros and their opponents have hit the over in 77 of their 158 games with a total this season.
• In 158 games with a line this season, the Astros have a mark of 79-79-0 against the spread.
• The Athletics have won 46 of the 119 games they were the moneyline underdog this season (38.7%).
• The Athletics have gone 16-34 when they have played as a moneyline underdog with odds of +136 or longer (32%).
• The Athletics have combined with their opponents to go over the total 82 times this season for an 82-73-2 record against the over/under.
• The Athletics have put together a 75-82-0 record ATS this season.

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.432), slugging percentage (.603) and total hits (174) this season. He has a .316 batting average.
• Among all qualified hitters in MLB, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Alvarez has hit safely in eight straight games. During his last 10 games he is batting .375 with three doubles, three home runs, eight walks and six RBIs.
• Isaac Paredes is batting .261 with 27 doubles, a triple, 23 home runs and 68 walks, while slugging .441 with an on-base percentage of .359.
• He ranks 62nd in batting average, 31st in on-base percentage and 53rd in slugging among qualifying hitters.
• Paredes heads into this game looking to extend his two-game hit streak. In his last five games he is hitting .389 with a double, two home runs, three walks and six RBIs.
• Christian Walker has 123 hits this season and has a slash line of .221/.293/.409.
• Walker enters this matchup with two games in a row with at least one hit. During his last five outings he is batting .200 with a home run, a walk and three RBIs.
• Jose Altuve has 16 home runs, 46 RBI and a batting average of .252 this season.
• Altuve has safely hit in seven straight games. During his last 10 games he is batting .317 with two doubles, a home run, a walk and two RBIs.

Athletics Player Leaders

• Jeff McNeil has accumulated a team-high .364 slugging percentage. He's batting .265 with an on-base percentage of .314.
• Including all qualified hitters in the big leagues, his batting average puts him 49th, his on-base percentage ranks 97th, and he is 120th in slugging.
• Shea Langeliers is batting .266 with 21 doubles, 23 home runs and 35 walks. He's slugging .485 with an on-base percentage of .330.
• Zack Gelof is hitting .256 with 16 doubles, two triples, 20 home runs and 30 walks.
• Lawrence Butler's 107 hits and .325 OBP both lead his team.

Astros vs Athletics Head to Head

• 8/23/2026: 7-6 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 8/22/2026: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +215)
• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/25/2025: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!