Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 6:11 p.m.

In MLB action on Thursday, the Boston Red Sox take on the Cleveland Guardians.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Guardians Game Info

• Boston Red Sox (85-73) vs. Cleveland Guardians (82-76)
• Date: Thursday, September 24, 2026
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CleGuardians.TV

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-130) | CLE: (+110)
• Spread: BOS: -1.5 (+162) | CLE: +1.5 (-196)
• Total: 6.5 -- Over: (-122) | Under: (+100)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Ranger Suarez (Red Sox) - 8-4, 3.27 ERA vs Daniel Espino (Guardians) - 0-0, 4.73 ERA

The probable pitchers are Ranger Suarez (8-4) for the Red Sox and Daniel Espino for the Guardians. Suarez and his team are 15-12-0 ATS this season when he starts. Suarez's team is 12-8 this season when he starts and they are the moneyline favorite. Espino has started two games with set spreads, and the Guardians went 1-1-0. The Guardians have not been the underdog on the moneyline when Espino starts this season.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (62.6%)

Red Sox vs Guardians Moneyline

• Looking at the moneyline for Red Sox-Guardians, Boston is the favorite at -130, and Cleveland is +110 playing on the road.

Red Sox vs Guardians Spread

• The Red Sox are hosting the Guardians and are favored by 1.5 runs (+162 to cover) on the runline. Cleveland is -196 to cover.

Red Sox vs Guardians Over/Under

• Red Sox versus Guardians, on Sept. 24, has an over/under of 6.5, with the over being -122 and the under +100.

Bet on Boston Red Sox vs. Cleveland Guardians on FanDuel today!

Red Sox vs Guardians Betting Trends

• The Red Sox have been victorious in 59, or 54.6%, of the 108 contests they have been chosen as favorites in this season.
• This season Boston has been victorious 37 times in 68 chances when named as a favorite of at least -130 on the moneyline.
• The Red Sox and their opponents have gone over in 68 of their 155 games with a total set by sportsbooks this season.
• The Red Sox are 73-82-0 against the spread in their 155 games with a line set by sportsbooks this season.
• The Guardians have won 29 of the 57 games they were listed as the moneyline underdog this season (50.9%).
• Cleveland has a record of 19-15 when it has played as a moneyline underdog with odds of +110 or longer (55.9%).
• The Guardians have played in 149 games with a set over/under, and have combined with their opponents to go over the total 73 times (73-76-0).
• The Guardians have a 71-78-0 record ATS this season (covering 47.7% of the time).

Red Sox Player Leaders

• Wilyer Abreu is batting .253 with 37 doubles, four triples, 24 home runs and 70 walks. He has an on-base percentage of .332 and a slugging percentage of .454.
• He ranks 74th in batting average, 67th in on-base percentage, and 40th in slugging among qualified hitters in MLB.
• Abreu will look for his third straight game with a hit in this contest. During his last five outings he is batting .222 with a double and three walks.
• Caleb Durbin is batting .252 with 25 doubles, a triple, 13 home runs and 50 walks, while slugging .384 with an on-base percentage of .336.
• He is 76th in batting average, 60th in on-base percentage and 105th in slugging in the majors.
• Willson Contreras leads Boston with 123 hits and an OBP of .387 this season.
• Contreras enters this game with two games in a row with at least one hit. In his last five games he is batting .267 with a home run, two walks and two RBIs.
• Ceddanne Rafaela has an OPS of .763, fueled by an OBP of .319 and a team-best slugging percentage of .444 this season.
• Rafaela heads into this matchup on a two-game hitting streak. In his last five games he is hitting .267 with three RBIs.

Guardians Player Leaders

• Chase DeLauter is leading the Guardians with 140 hits. He's batting .290 and slugging .455 with an on-base percentage of .364.
• Including all the qualifying hitters in the majors, he ranks 10th in batting average, 24th in on-base percentage and 39th in slugging percentage.
• Steven Kwan's .379 OBP and .346 slugging percentage both lead his team. He has a batting average of .282.
• Including all qualifying hitters, his batting average puts him 19th, his on-base percentage ranks 11th, and he is 130th in slugging.
• Jose Ramirez is batting .235 with 27 doubles, 12 home runs and 59 walks.
• Brayan Rocchio is batting .250 with 24 doubles, two triples, 13 home runs and 37 walks.

Red Sox vs Guardians Head to Head

• 9/23/2026: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/22/2026: 3-2 CLE (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/31/2026: 9-4 BOS (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/30/2026: 9-1 BOS (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/29/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/3/2025: 8-1 CLE (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/1/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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