Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 1:12 a.m.

The Boston Red Sox will face the Cleveland Guardians in MLB action on Thursday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Guardians Game Info

• Boston Red Sox (85-73) vs. Cleveland Guardians (82-76)
• Date: Thursday, September 24, 2026
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CleGuardians.TV

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-134) | CLE: (+116)
• Spread: BOS: -1.5 (+168) | CLE: +1.5 (-205)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Ranger Suarez (Red Sox) - 8-4, 3.27 ERA vs Daniel Espino (Guardians) - 0-0, 4.73 ERA

The probable pitchers are Ranger Suarez (8-4) for the Red Sox and Daniel Espino for the Guardians. Suarez and his team have a record of 15-12-0 against the spread when he starts. Suarez's team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 12-8. Espino has started two games with set spreads, and the Guardians went 1-1-0. The Guardians have yet to be named a moneyline underdog when Espino starts this season.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (59.6%)

Red Sox vs Guardians Moneyline

• Looking at the moneyline for Red Sox-Guardians, Boston is the favorite at -134, and Cleveland is +116 playing on the road.

Red Sox vs Guardians Spread

• The Guardians are +1.5 on the run line against the Red Sox. The Guardians are -205 to cover, and the Red Sox are +168.

Red Sox vs Guardians Over/Under

• Red Sox versus Guardians, on Sept. 24, has an over/under of 7.5, with the over being -110 and the under -110.

Bet on Boston Red Sox vs. Cleveland Guardians on FanDuel today!

Red Sox vs Guardians Betting Trends

• The Red Sox have been chosen as favorites in 108 games this year and have walked away with the win 59 times (54.6%) in those games.
• This year Boston has won 32 of 61 games when listed as at least -134 on the moneyline.
• Contests with the Red Sox have gone over the total set by sportsbooks in 68 of 155 chances this season.
• In 155 games with a line this season, the Red Sox have a mark of 73-82-0 against the spread.
• The Guardians have been the underdog on the moneyline 57 total times this season. They've gone 29-28 in those games.
• When it has played as a moneyline underdog with odds of +116 or longer, Cleveland has a 14-11 record (winning 56% of its games).
• In the 149 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 73 times (73-76-0).
• The Guardians have a 71-78-0 record ATS this season (covering 47.7% of the time).

Red Sox Player Leaders

• Wilyer Abreu is batting .253 with 37 doubles, four triples, 24 home runs and 70 walks. He has an on-base percentage of .332 while slugging .454.
• He is 76th in batting average, 66th in on-base percentage, and 40th in slugging among all qualified hitters in MLB.
• Abreu has recorded at least one hit in two games in a row. In his last five games he is batting .222 with a double and three walks.
• Caleb Durbin has 25 doubles, a triple, 13 home runs and 50 walks. He's batting .252 and slugging .384 with an on-base percentage of .336.
• His batting average ranks 77th among qualified players, his on-base percentage 60th, and his slugging percentage 106th.
• Willson Contreras has 123 hits and an OBP of .387, both of which lead the Red Sox this season.
• Contreras takes a two-game hitting streak into this matchup. During his last five outings he is batting .267 with a home run, two walks and two RBIs.
• Ceddanne Rafaela has an OPS of .763, fueled by an OBP of .319 and a team-best slugging percentage of .444 this season.
• Rafaela has safely hit in two straight games. In his last five games he is batting .267 with three RBIs.

Guardians Player Leaders

• Chase DeLauter leads the Guardians with 140 hits. He's batting .290 and slugging .455 with an on-base percentage of .364.
• Including all the qualified players in the big leagues, his batting average is 11th, his on-base percentage is 20th, and he is 39th in slugging.
• Steven Kwan has a .379 OBP while slugging .346. Both are team-highs. He has a batting average of .282.
• Including all qualified hitters, his batting average puts him 19th, his on-base percentage ranks 10th, and he is 130th in slugging.
• Jose Ramirez is batting .235 with 27 doubles, 12 home runs and 59 walks.
• Brayan Rocchio is hitting .250 with 24 doubles, two triples, 13 home runs and 37 walks.

Red Sox vs Guardians Head to Head

• 9/23/2026: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/22/2026: 3-2 CLE (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/31/2026: 9-4 BOS (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/30/2026: 9-1 BOS (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/29/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/3/2025: 8-1 CLE (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/1/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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