Alabama vs Vanderbilt Prediction, Odds, Picks, Best Bets for Week 6 2025

Saturday's slate in college football includes a matchup between the Alabama Crimson Tide and the Vanderbilt Commodores.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Alabama vs Vanderbilt Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Alabama: (-510) | Vanderbilt: (+390)
• Spread: Alabama: -12.5 (-110) | Vanderbilt: +12.5 (-110)
• Total: 56.5 -- Over: (-120) | Under: (-102)

Alabama vs Vanderbilt Betting Trends

• Alabama is 3-1-0 against the spread this year.
• As at least a 12.5-point favorite, Alabama has two wins ATS (2-1).
• This season, three of Alabama's four games have go over the point total.
• Vanderbilt has four wins in five contests against the spread this season.
• Of five Vanderbilt games so far this year, three have hit the over.

Alabama vs Vanderbilt Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Crimson Tide win (81%)

Alabama vs Vanderbilt Point Spread

Vanderbilt is an underdog by 12.5 points against Alabama. Vanderbilt is -110 to cover the spread, and Alabama is -110.

Alabama vs Vanderbilt Over/Under

A total of 56.5 points has been set for the Alabama-Vanderbilt game on Oct. 4, with the over available at -120 and the under at -102.

Alabama vs Vanderbilt Moneyline

Looking at the moneyline for Vanderbilt-Alabama, Vanderbilt is the underdog at +390, and Alabama is -510.

Alabama vs. Vanderbilt Points Insights

Alabama vs. Vanderbilt Game Info

• Game day: Saturday, October 4, 2025
• Game time: 3:30 p.m. ET
• TV channel: ABC
• Location: Tuscaloosa, Alabama
• Stadium: Bryant-Denny Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Alabama vs. Vanderbilt analysis on FanDuel Research.