Alabama vs Vanderbilt Prediction, Odds, Picks, Best Bets for Week 6 2025

In college football action on Saturday, the Alabama Crimson Tide play the Vanderbilt Commodores.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Alabama vs Vanderbilt Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Alabama: (-429) | Vanderbilt: (+330)
• Spread: Alabama: -10.5 (-115) | Vanderbilt: +10.5 (-105)
• Total: 55.5 -- Over: (-110) | Under: (-110)

Alabama vs Vanderbilt Betting Trends

• Against the spread, Alabama is 3-1-0 this year.
• Alabama has two wins ATS (2-1) as a 10.5-point or higher favorite in 2025.
• This season, three of Alabama's four games have go over the point total.
• Against the spread, Vanderbilt is 4-1-0 this season.
• This year, three of Vanderbilt's five games have gone over the point total.

Alabama vs Vanderbilt Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Crimson Tide win (79.3%)

Alabama vs Vanderbilt Point Spread

Alabama is favored by 10.5 points against Vanderbilt. Alabama is -115 to cover the spread, while Vanderbilt is -105.

Alabama vs Vanderbilt Over/Under

The over/under for the Alabama versus Vanderbilt matchup on Oct. 4 has been set at 55.5, with -110 odds on the over and -110 odds on the under.

Alabama vs Vanderbilt Moneyline

Looking at the moneyline for Vanderbilt-Alabama, Vanderbilt is the underdog at +330, and Alabama is -429.

Alabama vs. Vanderbilt Points Insights

Alabama vs. Vanderbilt Game Info

• Game day: Saturday, October 4, 2025
• Game time: 3:30 p.m. ET
• TV channel: ABC
• Location: Tuscaloosa, Alabama
• Stadium: Bryant-Denny Stadium

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Check out even more in-depth Alabama vs. Vanderbilt analysis on FanDuel Research.