Alabama vs South Carolina Prediction, Odds, Picks, Best Bets for Week 9 2025

Saturday's slate in college football includes a matchup between the Alabama Crimson Tide and the South Carolina Gamecocks.

We've got you covered, in terms of the vital info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Alabama vs South Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Alabama: (-481) | South Carolina: (+370)
• Spread: Alabama: -11.5 (-115) | South Carolina: +11.5 (-105)
• Total: 47.5 -- Over: (-110) | Under: (-110)

Alabama vs South Carolina Betting Trends

• Alabama is 5-2-0 against the spread this season.
• As 11.5-point favorites or more, Alabama is 3-1 against the spread.
• This season, three of Alabama's seven games have hit the over.
• Against the spread, South Carolina is 3-4-0 this year.
• Two South Carolina games (of seven) have hit the over this season.

Alabama vs South Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Crimson Tide win (68.2%)

Alabama vs South Carolina Point Spread

Alabama is favored by 11.5 points versus South Carolina. Alabama is -115 to cover the spread, while South Carolina is -105.

Alabama vs South Carolina Over/Under

A total of 47.5 points has been set for the Alabama-South Carolina matchup on Oct. 25, with the over available at -110 and the under at -110.

Alabama vs South Carolina Moneyline

South Carolina is the underdog, +370 on the moneyline, while Alabama is a -481 favorite.

Alabama vs. South Carolina Points Insights

Alabama vs. South Carolina Game Info

• Game day: Saturday, October 25, 2025
• Game time: 3:30 p.m. ET
• TV channel: ABC
• Location: Columbia, South Carolina
• Stadium: Williams-Brice Stadium

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Check out even more in-depth Alabama vs. South Carolina analysis on FanDuel Research.