76ers vs. Cavaliers Prediction, Odds, Picks, Best Bets for Jan. 16

76ers vs. Cavaliers Game Info

• Date: Friday, January 16, 2026
• Time: 7 p.m. ET
• Venue: Xfinity Mobile Arena -- Philadelphia, Pennsylvania
• Coverage: ESPN, NBCS-PH, and FDSOH

Two of the league's top scorers face off when Tyrese Maxey (third, 30.5 PPG) and the Philadelphia 76ers (22-17) host Donovan Mitchell (fourth, 29.7 PPG) and the Cleveland Cavaliers (23-19) on Friday, January 16, 2026 at 7 p.m. ET on ESPN, NBCS-PH, and FDSOH. The 76ers are 2.5-point favorites. The matchup has an over/under of 233.5.

76ers vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

76ers vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: 76ers win (51.8%)

76ers vs. Cavaliers Betting Trends

• The 76ers have covered the spread 21 times this season (21-17-1).
• Against the spread, the Cavaliers are 15-27-0 this season.
• Games involving the 76ers have hit the over 21 times out of 42 chances this season.
• Cavaliers games this year have gone over the total in 20 of 42 opportunities (47.6%).
• Philadelphia owns a worse record against the spread at home (8-11-1) than it does in road games (13-6-0).
• The 76ers have hit the over on the over/under in a higher percentage of games at home (55%) than away games (52.6%).
• This season, Cleveland is 8-16-0 at home against the spread (.333 winning percentage). On the road, it is 7-11-0 ATS (.389).
• Cavaliers games have finished above the over/under 37.5% of the time at home (nine of 24), and 61.1% of the time on the road (11 of 18).

76ers Leaders

• Maxey averages 30.5 points, 4.4 rebounds and 6.6 assists, shooting 47.6% from the field and 40.5% from downtown, with 3.7 made 3-pointers per contest (fourth in league).
• VJ Edgecombe's numbers on the season are 15.9 points, 5.3 rebounds and 4.3 assists per contest, shooting 42.5% from the field and 37.6% from downtown, with an average of 2.3 made 3-pointers.
• Quentin Grimes is averaging 14 points, 3.9 rebounds and 3.8 assists. Defensively, he averages 1 steal and 0.5 blocked shots.
• Joel Embiid is averaging 23.5 points, 7 rebounds and 3.3 assists.
• Andre Drummond's numbers on the season are 7 points, 8.8 boards and 0.8 assists per contest, shooting 50.3% from the field.

Cavaliers Leaders

• Per game, Mitchell provides the Cavaliers 29.7 points, 4.7 rebounds and 5.6 assists. He also averages 1.5 steals (10th in NBA) and 0.3 blocks.
• Per game, Evan Mobley gives the Cavaliers 17.9 points, 8.7 rebounds and 4.1 assists. He also averages 1 steal and 1.9 blocks (fourth in league).
• Per game, Jaylon Tyson gets the Cavaliers 12.8 points, 5.3 rebounds and 2 assists, plus 1 steal and 0.5 blocks.
• Jarrett Allen's numbers on the season are 13.5 points, 7.9 boards and 2.2 assists per contest. He is making 59.6% of his shots from the field (ninth in NBA).
• De'Andre Hunter's numbers on the season are 14 points, 4.3 boards and 2.2 assists per game. He is making 42.8% of his shots from the field and 30.7% from beyond the arc, with an average of 1.7 treys.

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