49ers vs Colts Prediction, Odds, Picks, Best Bets for NFL Week 16 Monday Night Football

NFL action on Monday includes the San Francisco 49ers taking on the Indianapolis Colts.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info about today's NFL betting odds.

49ers vs Colts Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (59.8%)

49ers vs Colts Point Spread

The 49ers are 6.5-point favorites against the Colts. The 49ers are -104 to cover the spread, while the Colts are -118 to cover as a 6.5-point underdog.

49ers vs Colts Over/Under

49ers versus Colts on Dec. 22 has an over/under of 46.5 points, with the over -115 and the under -105.

49ers vs Colts Moneyline

The 49ers vs Colts moneyline has the 49ers as a -295 favorite, while the Colts are a +240 underdog at home.

49ers vs Colts Betting Trends

• San Francisco's record against the spread is 9-5-0.
• The 49ers are unbeaten ATS (2-0) as a 6.5-point favorite or greater this season.
• There have been eight 49ers games (out of 14) that went over the total this year.
• The Colts are 8-6-0 against the spread this season.
• Indianapolis has yet to lose ATS (1-0) as a 6.5-point underdog or more this season.
• The Colts have played 14 games this season, and seven of them have gone over the total.

Check out even more in-depth 49ers vs. Colts analysis on FanDuel Research.

49ers vs Colts Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-295) | IND: (+240)
• Spread: SF: -6.5 (-104) | IND: +6.5 (-118)
• Total: 46.5 -- Over: (-115) | Under: (-105)

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