49ers vs Colts Prediction, Odds, Picks, Best Bets for NFL Week 16 Monday Night Football

The NFL slate on Monday includes the San Francisco 49ers taking on the Indianapolis Colts.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

49ers vs Colts Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (53.4%)

49ers vs Colts Point Spread

The 49ers are 4.5-point favorites against the Colts. The 49ers are -115 to cover the spread, while the Colts are -105 to cover as a 4.5-point underdog.

49ers vs Colts Over/Under

The over/under for 49ers-Colts on Dec. 22 is 46.5. The over is -105, and the under is -115.

49ers vs Colts Moneyline

San Francisco is a -245 favorite on the moneyline, while Indianapolis is a +200 underdog at home.

49ers vs Colts Betting Trends

• San Francisco is 9-5-0 against the spread this season.
• The 49ers are unbeaten ATS (3-0) as a 4.5-point favorite or greater this season.
• There have been eight 49ers games (out of 14) that hit the over this season.
• Against the spread, the Colts are 8-6-0 this year.
• Indianapolis has yet to lose ATS (2-0) as a 4.5-point underdog or greater this year.
• The Colts have played 14 games this year, and seven of them have gone over the total.

Check out even more in-depth 49ers vs. Colts analysis on FanDuel Research.

49ers vs Colts Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-245) | IND: (+200)
• Spread: SF: -4.5 (-115) | IND: +4.5 (-105)
• Total: 46.5 -- Over: (-105) | Under: (-115)

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