Week 6's "Thursday Night Football" showdown features the biggest spread of the slate, with the New England Patriots listed as 16.5-point favorites over the New York Giants, according to FanDuel Sportsbook.
While the spread is certainly telling, there are some other trends that could point to another dominant showing from New England in Week 6.
For one, the Giants are starting impressive first-year quarterback Daniel Jones, but rookie QBs have not fared well against Bill Belichick and the Patriots. Rookie signal-callers are 3-16 straight up against New England since 2010.
Jones already had a big hill to climb against a Patriots team that has won 15 consecutive regular-season home games since 2017, and he'll have to attempt to do it without most of his top skill-position players.
Saquon Barkley, Wayne Gallman and Sterling Shepard have already been ruled out, and New York's go-to receiver, Evan Engram, might not be able to suit up due to a sprained MCL.
Meanwhile, the Patriots are one of only nine defenses since 1940 to have allowed 34 points or fewer through their first five games of a season. New England's points allowed stat is also a tad bit inflated too, as 14 of those points have come from a blocked punt TD and a pick-six score.
New England's defense currently ranks first in the NFL in points per game (6.8), passing yards per game (160.4), QB rating (44.0), sacks (24), QB hits (39), sack percentage (11.8) and interceptions (11).
With rookie QB Daniel Jones being forced to play without a full complement of weapons, he could struggle to get points on the board against a defense that's off to a historically great start.
Join FanDuel Sportsbook Today. New users get a risk-free bet up to $500. Join Now.
Max Staley is not a FanDuel employee. In addition to providing DFS gameplay advice, Max Staley also participates in DFS contests on FanDuel using his personal account, username mstaley1212. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.