Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 14

Odds updated as of 2:12 a.m.

On Monday in MLB, the St. Louis Cardinals are up against the San Francisco Giants.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Giants Game Info

• St. Louis Cardinals (74-76) vs. San Francisco Giants (62-88)
• Date: Monday, September 14, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and NBCS-BA

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-132) | SF: (+112)
• Spread: STL: -1.5 (+176) | SF: +1.5 (-215)
• Total: 8 -- Over: (-105) | Under: (-115)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Quinn Mathews (Cardinals) - 1-3, 4.11 ERA vs Landen Roupp (Giants) - 9-13, 4.00 ERA

The Cardinals will look to Quinn Mathews (1-3) against the Giants and Landen Roupp (9-13). Mathews' team is 2-4-0 against the spread this season in his starts. Mathews' team is 1-1 this season when he starts and they're favored on the moneyline. The Giants have a 10-18-0 record against the spread in Roupp's starts. The Giants are 9-11 in Roupp's 20 starts this season that they were the underdog on the moneyline.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (52.2%)

Cardinals vs Giants Moneyline

• The moneyline numbers for Cardinals vs. Giants reveal St. Louis as the favorite (-132) and San Francisco as the underdog (+112) on the road.

Cardinals vs Giants Spread

• The Giants are at +1.5 on the runline against the Cardinals. The Giants are -215 to cover the spread, and the Cardinals are +176.

Cardinals vs Giants Over/Under

• A combined run total of 8 has been set for Cardinals-Giants on Sept. 14, with the over at -105 and the under at -115.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have come away with 26 wins in the 48 contests they have been listed as the favorites in this season.
• This season St. Louis has been victorious seven times in 11 chances when named as a favorite of at least -132 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 67 of their 146 opportunities.
• The Cardinals have posted a record of 80-66-0 against the spread this season.
• The Giants have won 37 of the 101 games they were the underdog on the moneyline this season (36.6%).
• San Francisco has gone 24-37 when it has played as a moneyline underdog with odds of +112 or longer (39.3%).
• The Giants have played in 147 games with a set over/under, and have combined with their opponents to go over the total 72 times (72-65-10).
• The Giants have covered 47.6% of their games this season, going 70-77-0 ATS.

Cardinals Player Leaders

• Alec Burleson leads St. Louis in slugging percentage (.466) thanks to 59 extra-base hits. He has a .283 batting average and an on-base percentage of .349.
• Among all qualifying hitters, he is 18th in batting average, his on-base percentage ranks 44th, and he is 34th in slugging.
• Jordan Walker has 159 hits, which is best among St. Louis batters this season. He's batting .281 with 61 extra-base hits. He's also slugging .488 with an on-base percentage of .336.
• Among all qualifying players, he is 22nd in batting average, 60th in on-base percentage and 22nd in slugging percentage.
• Ivan Herrera leads St. Louis in OBP (.357) this season, fueled by 138 hits.
• Nathan Church has been key for St. Louis with 100 hits, an OBP of .299 plus a slugging percentage of .376.
• Church has safely hit in 12 straight games. During his last 10 outings he is hitting .382 with three doubles, three walks and three RBIs.

Giants Player Leaders

• Jung Hoo Lee has 29 doubles, four triples, nine home runs and 27 walks while batting .276. He's slugging .400 with an on-base percentage of .318.
• Including all qualified hitters in the majors, he is 31st in batting average, 90th in on-base percentage and 88th in slugging percentage.
• Bryce Eldridge is batting .269 with 22 doubles, 16 home runs and 55 walks. He's slugging .455 with an on-base percentage of .359.
• Drew Gilbert has 14 doubles, three triples, nine home runs and 35 walks while batting .234.
• Christian Koss is batting .235 with five doubles, four home runs and nine walks.

Cardinals vs Giants Head to Head

• 9/9/2026: 7-6 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/8/2026: 2-1 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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