Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 14

Odds updated as of 7:12 p.m.

The Monday schedule in MLB includes a matchup between the St. Louis Cardinals and the San Francisco Giants.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Giants Game Info

• St. Louis Cardinals (74-76) vs. San Francisco Giants (62-88)
• Date: Monday, September 14, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and NBCS-BA

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-146) | SF: (+124)
• Spread: STL: -1.5 (+146) | SF: +1.5 (-176)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Quinn Mathews (Cardinals) - 1-3, 4.11 ERA vs Landen Roupp (Giants) - 9-13, 4.00 ERA

This contest's pitching matchup is set, as the Cardinals will send Quinn Mathews (1-3) to the mound, while Landen Roupp (9-13) will take the ball for the Giants. Mathews' team is 2-4-0 against the spread in his starts this season. Mathews' team is 1-1 this season when he starts and they're favored on the moneyline. The Giants have a 10-18-0 ATS record in Roupp's 28 starts with a set spread. The Giants are 9-11 in Roupp's 20 starts this season that they were the moneyline underdog.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (50.5%)

Cardinals vs Giants Moneyline

• Looking at the moneyline for Giants-Cardinals, San Francisco is the underdog at +124, and St. Louis is -146 playing at home.

Cardinals vs Giants Spread

• The Cardinals are favored by 1.5 runs at home versus the Giants. The Cardinals are +146 to cover the spread, while the Giants are -176.

Cardinals vs Giants Over/Under

• A total of 7.5 runs has been set for the Cardinals-Giants contest on Sept. 14, with the over available at -120 and the under at -102.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have been victorious in 26, or 54.2%, of the 48 contests they have been chosen as favorites in this season.
• St. Louis has a record of 5-2 when favored by -146 or more this year.
• The Cardinals and their opponents have gone over in 67 of their 146 games with a total set by sportsbooks this season.
• In 146 games with a line this season, the Cardinals have a mark of 80-66-0 against the spread.
• The Giants have won 37 of the 101 games they were the moneyline underdog this season (36.6%).
• San Francisco has gone 17-27 in games it has played as a moneyline underdog with odds of +124 or longer (38.6%).
• The Giants have combined with opponents to go over the total 72 times this season for a 72-65-10 record against the over/under.
• The Giants have a 70-77-0 record ATS this season (covering 47.6% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis with a slugging percentage of .466, fueled by 59 extra-base hits. He has a .283 batting average and an on-base percentage of .349.
• Among qualified batters in the majors, he is 18th in batting average, 44th in on-base percentage, and 34th in slugging.
• Jordan Walker has 159 hits, which leads St. Louis batters this season. He's batting .281 with 61 extra-base hits. He's also slugging .488 with an on-base percentage of .336.
• His batting average is 22nd among qualified players, his on-base percentage 60th, and his slugging percentage 22nd.
• Ivan Herrera leads St. Louis in OBP (.357) this season, fueled by 138 hits.
• Nathan Church has been key for St. Louis with 100 hits, an OBP of .299 plus a slugging percentage of .376.
• Church brings a 12-game hitting streak into this game. During his last 10 games he is hitting .382 with three doubles, three walks and three RBIs.

Giants Player Leaders

• Jung Hoo Lee is batting .276 with 29 doubles, four triples, nine home runs and 27 walks. He's slugging .400 with an on-base percentage of .318.
• Including all the qualified hitters in MLB, he is 31st in batting average, 90th in on-base percentage and 88th in slugging percentage.
• Bryce Eldridge has 22 doubles, 16 home runs and 55 walks while hitting .269. He's slugging .455 with an on-base percentage of .359.
• Drew Gilbert is hitting .234 with 14 doubles, three triples, nine home runs and 35 walks.
• Christian Koss has five doubles, four home runs and nine walks while hitting .235.

Cardinals vs Giants Head to Head

• 9/9/2026: 7-6 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/8/2026: 2-1 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!