Yankees vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 4:12 p.m.

The MLB schedule on Sunday includes the San Diego Padres taking on the New York Yankees.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Yankees Game Info

• San Diego Padres (74-68) vs. New York Yankees (81-61)
• Date: Sunday, September 6, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and YES

Padres vs Yankees Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-112) | NYY: (-104)
• Spread: SD: +1.5 (-194) | NYY: -1.5 (+160)
• Total: 7 -- Over: (-105) | Under: (-115)

Padres vs Yankees Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 9-9, 3.11 ERA vs Gerrit Cole (Yankees) - 8-7, 3.29 ERA

The Padres will look to Michael King (9-9) against the Yankees and Gerrit Cole (8-7). King and his team are 10-18-0 ATS this season when he starts. King's team has won 44.4% of his starts when they are favored on the moneyline (8-10). The Yankees have a 7-11-0 ATS record in Cole's 18 starts that had a set spread. The Yankees have been the underdog on the moneyline in three of Cole's starts this season, and they went 1-2 in those matchups.

Padres vs Yankees Moneyline

• Looking at the moneyline for Yankees-Padres, New York is the underdog at -104, and San Diego is -112 playing at home.

Padres vs Yankees Spread

• The Yankees are 1.5-run favorites against the spread for this matchup with the Padres. The Yankees are +160 to cover, while the Padres are -194 to cover as a 1.5-run underdog on the runline.

Padres vs Yankees Over/Under

• A combined run total of 7 has been set for Padres-Yankees on Sept. 6, with the over at -105 and the under at -115.

Bet on San Diego Padres vs. New York Yankees on FanDuel today!

Padres vs Yankees Betting Trends

• The Padres have been victorious in 35, or 54.7%, of the 64 contests they have been chosen as favorites in this season.
• This season San Diego has come away with a win 34 times in 61 chances when named as a favorite of at least -112 on the moneyline.
• The Padres and their opponents have hit the over in 62 of their 142 games with a total set by oddsmakers this season.
• The Padres have posted a record of 82-60-0 against the spread this season.
• The Yankees have won 14 of the 26 games they were the moneyline underdog this season (53.8%).
• New York is 14-10 (winning 58.3% of its games) when playing as a moneyline underdog of -104 or longer.
• The Yankees have combined with opponents to hit the over on the total 60 times this season for a 60-74-3 record against the over/under.
• The Yankees have gone 69-68-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 154 hits and an OBP of .347, plus a team-best slugging percentage of .444. He's batting .280.
• He is 22nd in batting average, 44th in on-base percentage, and 50th in slugging among all qualified hitters in baseball.
• Manny Machado is hitting .221 with 21 doubles, 25 home runs and 68 walks, while slugging .408 with an on-base percentage of .309.
• Among qualifying batters, he ranks 125th in batting average, 104th in on-base percentage and 86th in slugging percentage.
• Machado has picked up a hit in two games in a row. In his last five games he is batting .412 with a double, a home run, four walks and two RBIs.
• Jackson Merrill has 128 hits this season and has a slash line of .238/.291/.413.
• Ty France has 20 home runs, 62 RBI and a batting average of .292 this season.

Yankees Player Leaders

• Ben Rice has accumulated an on-base percentage of .355 and a slugging percentage of .528. Both lead the Yankees. He's batting .261.
• Including all qualified hitters in the majors, he ranks 60th in batting average, 36th in on-base percentage and seventh in slugging percentage.
• Rice brings a four-game hitting streak into this matchup. During his last five outings he is batting .429 with a home run, two walks and two RBIs.
• Luis Garcia's 130 hits pace his team. He has a batting average of .284 while slugging .544 with an on-base percentage of .317.
• His batting average ranks 15th among all qualified players, his on-base percentage is 92nd, and he is third in slugging.
• Cody Bellinger is batting .264 with 22 doubles, three triples, 12 home runs and 56 walks.
• Jazz Chisholm has 16 doubles, three triples, 19 home runs and 54 walks while batting .229.

Padres vs Yankees Head to Head

• 9/5/2026: 5-1 NYY (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/4/2026: 3-2 SD (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2025: 4-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/6/2025: 12-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/5/2025: 4-3 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/26/2024: 5-2 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/25/2024: 4-1 NYY (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/24/2024: 8-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/28/2023: 10-7 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/27/2023: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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