Vanderbilt vs Kentucky Prediction, Odds, Picks, Best Bets for Week 13 2025

The Saturday schedule in college football includes a matchup between the Vanderbilt Commodores and the Kentucky Wildcats.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Vanderbilt vs Kentucky Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Vanderbilt: (-300) | Kentucky: (+245)
• Spread: Vanderbilt: -7.5 (-110) | Kentucky: +7.5 (-110)
• Total: 53.5 -- Over: (-115) | Under: (-105)

Vanderbilt vs Kentucky Betting Trends

• Vanderbilt is 8-2-0 against the spread this season.
• As at least a 7.5-point favorite, Vanderbilt has two wins ATS (2-1).
• This season, six of Vanderbilt's 10 games have hit the over.
• Kentucky's record against the spread in 2025 is 5-5-0.
• Kentucky is 3-2 as 7.5-point or bigger underdogs in 2025.
• Kentucky has played 10 games this year, and six of them have gone over the total.

Vanderbilt vs Kentucky Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Commodores win (77%)

Vanderbilt vs Kentucky Point Spread

Kentucky is listed as an underdog by 7.5 points (-110 odds), and Vanderbilt, the favorite, is -110 to cover.

Vanderbilt vs Kentucky Over/Under

A combined point total of 53.5 has been set for Vanderbilt-Kentucky on Nov. 22, with the over at -115 and the under at -105.

Vanderbilt vs Kentucky Moneyline

Kentucky is the underdog, +245 on the moneyline, while Vanderbilt is a -300 favorite.

Vanderbilt vs. Kentucky Points Insights

Vanderbilt vs. Kentucky Game Info

• Game day: Saturday, November 22, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN
• Location: Nashville, Tennessee
• Stadium: FirstBank Stadium

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