Towson vs South Carolina Prediction, College Football Picks, Odds & Best Bets Tonight

College Football Betting Picks in Summary

• South Carolina -43.5
• Over 57.5
• South Carolina Over 543.5 Total Yards

Towson travels to South Carolina Saturday evening in one of the widest lines on the entire college football board — a 43.5-point spread with no moneyline even posted, a real sign of just how one-sided the market considers this one.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

Towson at South Carolina (Sat, 7:00 p.m. ET)

South Carolina -43.5 (-115)

South Carolina's own first-half spread alone sits at -25.5, more than half the full-game number — a genuine sign this one should be well in hand by halftime against an FCS opponent.

Over 57.5 (-110)

South Carolina's own projected yardage output (543.5) is enough on its own to comfortably clear this entire total, regardless of how little Towson manages to produce on the other side.

South Carolina Over 543.5 Total Yards (-114)

South Carolina's rushing attack alone is projected for 256.5 yards, meaning the passing game only needs to contribute another 287 or so to clear this number — a genuinely reasonable ask given the scale of the talent gap.