Tennessee vs Louisville College Basketball Prediction, Odds, Picks, Best Bets for Dec. 16

The Tennessee Volunteers (7-3) aim to end a three-game losing streak when they host the Louisville Cardinals (9-1) on December 16, 2025 at Thompson-Boling Arena. The contest airs on ESPN.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Tennessee vs. Louisville Game Info and Odds

• Game day: Tuesday, December 16, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Knoxville, Tennessee
• Arena: Thompson-Boling Arena

See these betting trends and insights before you wager on Tuesday's Tennessee-Louisville spread (Tennessee -2.5) or total (157.5 points).

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Tennessee vs. Louisville: ATS Betting Stats and Trends

• Tennessee has covered three times in 10 matchups with a spread this season.
• Louisville is 7-3-0 ATS this season.
• The Volunteers did a better job covering the spread in home games (9-8-0) last season than they did in road tilts (5-6-0).
• The Cardinals' winning percentage against the spread at home was .471 (8-9-0) last year. On the road, it was .818 (9-2-0).

Tennessee vs. Louisville: Moneyline Betting Stats

• Tennessee has come away with four wins in the seven contests it has been listed as the moneyline favorite in this season.
• This season, the Volunteers have been victorious four times in six chances when named as a favorite of at least -152 or shorter on the moneyline.
• Louisville is the moneyline underdog in its first game this season.
• The Cardinals have yet to play as a moneyline underdog of +126 or longer.
• Tennessee has an implied victory probability of 60.3% according to the moneyline set by oddsmakers for this matchup.

Tennessee vs. Louisville Head-to-Head Comparison

• Tennessee was 167th in college basketball in points scored (74.0 per game) and 10th-best in points allowed (63.1) last season.
• Tennessee was 105th in college basketball in rebounds per game (33.2) and 13th-best in rebounds conceded (27.5) last season.
• With 15.4 assists per game last season, Tennessee was 61st in college basketball.
• Tennessee was 40th in college basketball in turnovers per game (9.6) and 250th in turnovers forced (10.5) last season.
• With 78.5 points per game on offense, Louisville ranked 65th in college basketball last year. At the other end, it allowed 69.5 points per contest, which ranked 89th in college basketball.
• Last year Louisville grabbed 34.6 rebounds per game (47th-ranked in college basketball) and gave up 30.2 rebounds per contest (114th-ranked).
• Last season Louisville ranked 148th in college basketball in assists, averaging 13.9 per game.
• Louisville averaged 10.9 turnovers per game (150th-ranked in college basketball) this season, while forcing 12.2 turnovers per contest (93rd-ranked).

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