St. John's vs DePaul College Basketball Prediction, Odds, Picks, Best Bets for Dec. 16

The DePaul Blue Demons (8-3, 0-0 Big East) will try to build on a three-game winning streak when they visit the St. John's Red Storm (6-3, 0-0 Big East) on December 16, 2025 at Carnesecca Arena. The contest airs on Peacock.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

St. John's vs. DePaul Game Info and Odds

• Game day: Tuesday, December 16, 2025
• Game time: 7 p.m. ET
• TV channel: Peacock
• Location: Queens, New York
• Arena: Carnesecca Arena

St. John's vs. DePaul Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: St. John's win (94.9%)

Before you wager on Tuesday's St. John's-DePaul spread (St. John's -19.5) or total (151.5 points), see the betting trends and insights below.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

St. John's vs. DePaul: ATS Betting Stats and Trends

• St. John's has put together a 5-4-0 record against the spread this season.
• DePaul is 6-5-0 ATS this season.
• In home games last season, the Red Storm owned a worse record against the spread (10-8-0) compared to their ATS record on the road (6-4-0).
• The Blue Demons' winning percentage against the spread at home last year was .474 (9-10-0). Away, it was .417 (5-7-0).

St. John's vs. DePaul: Moneyline Betting Stats

• St. John's has been victorious in five of the seven contests it has been chosen as moneyline favorites in this season.
• The Red Storm have not lost in three games this year when favored by -4545 or better on the moneyline.
• DePaul has been the moneyline underdog three total times this season. DePaul has gone 1-2 in those games.
• The Blue Demons have not yet played as a moneyline underdog of +1600 or longer.
• The moneyline set for this matchup implies St. John's has a 97.8% chance of coming away with a victory in the contest.

St. John's vs. DePaul Head-to-Head Comparison

• St. John's averages 88.9 points per game (26th in college basketball) while giving up 73 per contest (178th in college basketball). It has a +143 scoring differential overall and outscores opponents by 15.9 points per game.
• Bryce Hopkins is 292nd in the nation with a team-leading 14.9 points per game.
• DePaul is outscoring opponents by 9.6 points per game, with a +105 scoring differential overall. It puts up 77.4 points per game (187th in college basketball) and allows 67.8 per outing (69th in college basketball).
• CJ Gunn paces DePaul, averaging 14.2 points per game (365th in college basketball).
• The Red Storm win the rebound battle by 5.6 boards on average. They record 36.7 rebounds per game, which ranks 51st in college basketball, while their opponents grab 31.1 per contest.
• Zuby Ejiofor tops the team with 7.2 rebounds per game (138th in college basketball action).
• The Blue Demons are 274th in the country at 31.1 rebounds per game. That's similar to the 30.3 their opponents average.
• N.J. Benson is 221st in the nation with 6.6 rebounds per game, leading the Blue Demons.
• St. John's records 102.2 points per 100 possessions (97th in college basketball), while allowing 84 points per 100 possessions (39th in college basketball).
• The Blue Demons record 99 points per 100 possessions (149th in college basketball), while allowing 86.8 points per 100 possessions (81st in college basketball).

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!