Southern Miss vs South Alabama Prediction, Odds, Picks, Best Bets for Week 13 2025

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The South Alabama Jaguars are among the college football squads playing on Saturday, versus the Southern Miss Golden Eagles.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

South Alabama vs Southern Miss Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: South Alabama: (-108) | Southern Miss: (-108)
Spread: South Alabama: -1.5 (-105) | Southern Miss: +1.5 (-115)
Total: 53.5 -- Over: (-105) | Under: (-115)

South Alabama has four wins in 10 games against the spread this year.
South Alabama has won twice ATS (2-5) as a 1.5-point or bigger favorite this season.
This season, six of South Alabama's 10 games have hit the over.
Southern Miss has beaten the spread five times in 10 games.
Southern Miss has one win ATS (1-2) as a 1.5-point underdog or greater this season.
This season, five of Southern Miss' 10 games have gone over the point total.

All college football win probability predictions and picks are according to numberFire.
Prediction: Golden Eagles win (63.2%)

Southern Miss is listed as an underdog by 1.5 points (-115 odds), and South Alabama, the favorite, is -105 to cover.

An over/under of 53.5 has been set for South Alabama-Southern Miss on Nov. 22, with the over being -105 and the under -115.

The South Alabama vs Southern Miss moneyline has Southern Miss as a -108 favorite, while South Alabama is a -108 underdog.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
South Alabama	25.0	91	28.1	91	53.4	10
Southern Miss	30.5	53	25.9	76	56.0	10

Check out even more in-depth South Alabama vs. Southern Miss analysis on FanDuel Research.

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