SMU vs Louisville Prediction, Odds, Picks, Best Bets for Week 13 2025

Saturday's slate in college football includes a matchup between the SMU Mustangs and the Louisville Cardinals.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

SMU vs Louisville Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SMU: (-178) | Louisville: (+150)
• Spread: SMU: -3.5 (-118) | Louisville: +3.5 (-104)
• Total: 50.5 -- Over: (-110) | Under: (-110)

SMU vs Louisville Betting Trends

• SMU is 4-5-0 against the spread this season.
• SMU has won twice ATS (2-3) as a 3.5-point or bigger favorite this year.
• This season, three of SMU's nine games have gone over the point total.
• Louisville is 3-7-0 against the spread this year.
• Louisville has covered every time (1-0) as a 3.5-point or greater underdog this year.
• There have been five Louisville games (out of 10) that hit the over this year.

SMU vs Louisville Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Mustangs win (53.1%)

SMU vs Louisville Point Spread

Louisville is listed as an underdog by 3.5 points (-104 odds), and SMU, the favorite, is -118 to cover.

SMU vs Louisville Over/Under

The SMU-Louisville game on Nov. 22 has been given an over/under of 50.5 points. The over is -110 and the under is -110.

SMU vs Louisville Moneyline

The moneyline numbers for SMU vs. Louisville reveal SMU as the favorite (-178) and Louisville as the underdog (+150).

SMU vs. Louisville Points Insights

SMU vs. Louisville Game Info

• Game day: Saturday, November 22, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN2
• Location: University Park, Texas
• Stadium: Gerald J. Ford Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth SMU vs. Louisville analysis on FanDuel Research.