LSU vs Western Kentucky Prediction, Odds, Picks, Best Bets for Week 13 2025

In college football action on Saturday, the LSU Tigers take on the Western Kentucky Hilltoppers.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

LSU vs Western Kentucky Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LSU: (-3448) | Western Kentucky: (+1300)
• Spread: LSU: -23.5 (-115) | Western Kentucky: +23.5 (-105)
• Total: 51.5 -- Over: (-115) | Under: (-105)

LSU vs Western Kentucky Betting Trends

• LSU's record against the spread is 3-7-0.
• LSU is winless ATS (0-2) as a 23.5-point favorite or greater this season.
• This year, three of LSU's 10 games have gone over the point total.
• Against the spread, Western Kentucky is 8-2-0 this year.
• There have been five Western Kentucky games (out of 10) that went over the total this year.

LSU vs Western Kentucky Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (93.6%)

LSU vs Western Kentucky Point Spread

Western Kentucky is a 23.5-point underdog against LSU. Western Kentucky is -105 to cover the spread, and LSU is -115.

LSU vs Western Kentucky Over/Under

LSU versus Western Kentucky, on Nov. 22, has an over/under of 51.5, with the over being -115 and the under -105.

LSU vs Western Kentucky Moneyline

Western Kentucky is the underdog, +1300 on the moneyline, while LSU is a -3448 favorite.

LSU vs. Western Kentucky Points Insights

LSU vs. Western Kentucky Game Info

• Game day: Saturday, November 22, 2025
• Game time: 7:45 p.m. ET
• TV channel: SEC Network
• Location: Baton Rouge, Louisiana
• Stadium: Tiger Stadium

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Check out even more in-depth LSU vs. Western Kentucky analysis on FanDuel Research.