Oregon vs USC Prediction, Odds, Picks, Best Bets for Week 13 2025

The Saturday slate in college football includes a matchup between the Oregon Ducks and the USC Trojans.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Oregon vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oregon: (-350) | USC: (+280)
• Spread: Oregon: -9.5 (-110) | USC: +9.5 (-110)
• Total: 59.5 -- Over: (-105) | Under: (-115)

Oregon vs USC Betting Trends

• Oregon is 5-5-0 against the spread this year.
• Oregon's ATS record as 9.5-point or bigger favorites is 4-3.
• Out of 10 Oregon games so far this season, five have gone over the total.
• USC's record against the spread in 2025 is 5-5-0.
• USC has covered every time (1-0) as a 9.5-point or greater underdog this season.
• There have been five USC games (out of 10) that hit the over this year.

Oregon vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Ducks win (74.7%)

Oregon vs USC Point Spread

Oregon is favored by 9.5 points over USC. Oregon is -110 to cover the spread, with USC being -110.

Oregon vs USC Over/Under

An over/under of 59.5 has been set for Oregon-USC on Nov. 22, with the over being -105 and the under -115.

Oregon vs USC Moneyline

The Oregon vs USC moneyline has Oregon as a -350 favorite, while USC is a +280 underdog.

Oregon vs. USC Points Insights

Oregon vs. USC Game Info

• Game day: Saturday, November 22, 2025
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: Eugene, Oregon
• Stadium: Autzen Stadium

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Check out even more in-depth Oregon vs. USC analysis on FanDuel Research.