Sabres vs Red Wings NHL Prediction, Odds, Picks, Best Bets for Oct. 22

The Buffalo Sabres are among the NHL teams playing on Wednesday, up against the Detroit Red Wings.

We've got you covered, in terms of the vital information about NHL betting lines, before you make your wager on FanDuel Sportsbook.

Sabres vs Red Wings Game Info

• Buffalo Sabres (2-4) vs. Detroit Red Wings (5-1)
• Date: Wednesday, October 22, 2025
• Time: 7:30 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: TNT

Sabres vs Red Wings Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Sabres vs Red Wings Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (52.9%)

Sabres vs Red Wings Puck Line

• The Red Wings are 1.5-goal underdogs against the Sabres. The Red Wings are -265 to cover the spread, and the Sabres are +210.

Sabres vs Red Wings Over/Under

• The over/under for the Sabres versus Red Wings game on Oct. 22 has been set at 6.5, with +112 odds on the over and -138 odds on the under.

Sabres vs Red Wings Moneyline

• Looking at the moneyline for Red Wings-Sabres, Detroit is the underdog at -108, and Buffalo is -113 playing at home.

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