Sabres vs Red Wings NHL Prediction, Odds, Picks, Best Bets for Oct. 22

The Buffalo Sabres are among the NHL teams playing on Wednesday, up against the Detroit Red Wings.

Get the latest NHL odds ahead of this game on FanDuel Sportsbook.

Sabres vs Red Wings Game Info

• Buffalo Sabres (2-4) vs. Detroit Red Wings (5-1)
• Date: Wednesday, October 22, 2025
• Time: 7:30 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: TNT

Sabres vs Red Wings Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Sabres vs Red Wings Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (52.9%)

Sabres vs Red Wings Puck Line

• The Red Wings are underdogs by 1.5 goals on the road versus the Sabres. The Red Wings are -265 to cover the spread, and the Sabres are +210.

Sabres vs Red Wings Over/Under

• The Sabres-Red Wings matchup on Oct. 22 has been given an over/under of 6.5 goals. The over is +106 and the under is -130.

Sabres vs Red Wings Moneyline

• Detroit is a -106 underdog on the moneyline, while Buffalo is a -113 favorite at home.

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