Sabres vs Blue Jackets NHL Prediction, Odds, Picks, Best Bets for Nov. 6

Friday's slate in the NHL includes a matchup between the Buffalo Sabres and the Columbus Blue Jackets.

Get the latest NHL odds ahead of this matchup on FanDuel Sportsbook.

Sabres vs Blue Jackets Game Info

• Buffalo Sabres (7-5-3) vs. Columbus Blue Jackets (7-7)
• Date: Friday, November 6, 2026
• Time: 7 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN+

Sabres vs Blue Jackets Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Sabres vs Blue Jackets Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (75.5%)

Sabres vs Blue Jackets Puck Line

• The Sabres are 1.5-goal favorites against the Blue Jackets. The Sabres are +134 to cover the spread, and the Blue Jackets are -164.

Sabres vs Blue Jackets Over/Under

• Sabres versus Blue Jackets on Nov. 6 has an over/under of 6.5 goals, with the over -102 and the under -120.

Sabres vs Blue Jackets Moneyline

• Columbus is the underdog, +146 on the moneyline, while Buffalo is a -178 favorite at home.

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