Sabres vs Blackhawks NHL Prediction, Odds, Picks, Best Bets for Nov. 21

The NHL's Friday slate includes the Buffalo Sabres taking on the Chicago Blackhawks.

Before you place your bet on this game at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Sabres vs Blackhawks Game Info

• Buffalo Sabres (7-9-4) vs. Chicago Blackhawks (10-6-4)
• Date: Friday, November 21, 2025
• Time: 7 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN+

Sabres vs Blackhawks Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Sabres vs Blackhawks Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (50.9%)

Sabres vs Blackhawks Puck Line

• The Sabres are 1.5-goal favorites against the Blackhawks. The Sabres are +134 to cover the spread, and the Blackhawks are -164.

Sabres vs Blackhawks Over/Under

• A total of 6.5 goals has been set for the Sabres-Blackhawks matchup on Nov. 21, with the over available at +104 and the under at -128.

Sabres vs Blackhawks Moneyline

• Looking at the moneyline for Sabres-Blackhawks, Buffalo is the favorite at -184, and Chicago is +152 playing on the road.

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