Reds vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 15

Odds updated as of 2:11 a.m.

Thursday's slate in the MLB includes a matchup between the Cincinnati Reds and the Chicago White Sox.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Reds vs White Sox Game Info

• Cincinnati Reds (20-24) vs. Chicago White Sox (14-29)
• Date: Thursday, May 15, 2025
• Time: 12:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and CHSN

Reds vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-230) | CHW: (+190)
• Spread: CIN: -1.5 (-114) | CHW: +1.5 (-105)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Reds vs White Sox Probable Starting Pitchers

Probable Pitchers: Nicholas Martínez (Reds) - 1-4, 4.23 ERA vs Bryse Wilson (White Sox) - 0-1, 4.88 ERA

The probable starters are Nicholas Martinez (1-4) for the Reds and Bryse Wilson (0-1) for the White Sox. Martínez's team is 2-6-0 against the spread in his starts this season. Martinez's team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox have gone 2-1-0 ATS in Wilson's three starts that had a set spread. The White Sox have been the moneyline underdog in three of Wilson's starts this season, and they went 2-1 in those games.

Reds vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (70.7%)

Reds vs White Sox Moneyline

• Chicago is a +190 underdog on the moneyline, while Cincinnati is a -230 favorite at home.

Reds vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Reds. The White Sox are -105 to cover the spread, and the Reds are -114.

Reds vs White Sox Over/Under

• Reds versus White Sox, on May 15, has an over/under of 9.5, with the over being -100 and the under -122.

Bet on Cincinnati Reds vs. Chicago White Sox on FanDuel today!

Reds vs White Sox Betting Trends

• The Reds have been chosen as favorites in 17 games this year and have walked away with the win nine times (52.9%) in those games.
• Oddsmakers have given Cincinnati the best odds of winning it has seen this season, with a -230 moneyline listed for this contest.
• The Reds' games have gone over the total in 18 of their 42 opportunities.
• In 42 games with a line this season, the Reds have a mark of 21-21-0 against the spread.
• The White Sox have a 13-28 record in games they were the underdog on the moneyline (winning 31.7% of those games).
• When it has played as a moneyline underdog with odds of +190 or longer, Chicago has gone 2-13 (13.3%).
• The White Sox have had an over/under set by oddsmakers 42 times, and have combined with opponents to go over the total in 19 of those games (19-21-2).
• The White Sox have a 23-19-0 record against the spread this season (covering 54.8% of the time).

Reds Player Leaders

• Elly De La Cruz has 43 hits to go with a slugging percentage of .407, both of which are best among Cincinnati hitters this season. He has a .250 batting average and an on-base percentage of .323.
• Among the qualifying hitters in baseball, his batting average ranks 91st, his on-base percentage ranks 92nd, and he is 86th in slugging.
• De La Cruz will look for his third straight game with a hit in this contest. During his last five outings he is batting .190 with a double, two home runs and five RBIs.
• TJ Friedl has an OPS of .741, fueled by an OBP of .359 and a team-best slugging percentage of .382 this season. He's batting .274.
• Among qualified hitters, his batting average places him 52nd, his on-base percentage 48th, and his slugging percentage 108th.
• Gavin Lux has 39 hits this season and a team-best OBP of .373.
• Jose Trevino has three home runs, 10 RBI and a batting average of .308 this season.

White Sox Player Leaders

• Luis Robert is hitting .190 with three doubles, five home runs and 21 walks. He's slugging .321 with an on-base percentage of .296.
• He is 156th in batting average, 124th in on-base percentage and 149th in slugging percentage among all qualifying hitters in the big leagues.
• Miguel Vargas leads his team with a .305 on-base percentage. He has a batting average of .214 while slugging .338.
• Including all qualified hitters, his batting average places him 140th, his on-base percentage ranks 115th, and he is 135th in slugging.
• Andrew Vaughn is hitting .194 with eight doubles, five home runs and seven walks.
• Lenyn Sosa has collected 40 hits while slugging .381. Both lead his team.

Reds vs White Sox Head to Head

• 5/14/2025: 4-2 CHW (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 4/14/2024: 11-4 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/13/2024: 5-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/12/2024: 11-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 5/7/2023: 17-4 CHW (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/6/2023: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/5/2023: 5-4 CHW (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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