Red Sox vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 7:12 p.m.

The MLB schedule on Friday includes the Boston Red Sox facing the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Giants Game Info

• Boston Red Sox (68-59) vs. San Francisco Giants (52-75)
• Date: Friday, August 21, 2026
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and NBCS-BA

Red Sox vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-172) | SF: (+158)
• Spread: BOS: -1.5 (+122) | SF: +1.5 (-146)
• Total: 7.5 -- Over: (+104) | Under: (-128)

Red Sox vs Giants Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Red Sox) - 15-3, 2.65 ERA vs Logan Webb (Giants) - 8-7, 3.50 ERA

The Red Sox will give the ball to Sonny Gray (15-3, 2.65 ERA), who is eyeing win No. 16 on the season, and the Giants will counter with Logan Webb (8-7, 3.50 ERA). Gray and his team have a record of 15-7-0 against the spread when he starts. Gray's team has a record of 13-6 this season when he starts and they are the favorite on the moneyline. The Giants have gone 10-12-0 ATS in Webb's 22 starts with a set spread. The Giants have a 2-6 record in Webb's eight starts this season when they were the moneyline underdog.

Red Sox vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (58.2%)

Red Sox vs Giants Moneyline

• San Francisco is a +158 underdog on the moneyline, while Boston is a -172 favorite at home.

Red Sox vs Giants Spread

• The Red Sox are 1.5-run home favorites on the runline against the Giants. The Red Sox are +122 to cover, and the Giants are -146.

Red Sox vs Giants Over/Under

• An over/under of 7.5 has been set for Red Sox-Giants on Aug. 21, with the over being +104 and the under -128.

Bet on Boston Red Sox vs. San Francisco Giants on FanDuel today!

Red Sox vs Giants Betting Trends

• The Red Sox have been chosen as favorites in 86 games this year and have walked away with the win 45 times (52.3%) in those games.
• Boston has a record of 5-5 in contests when oddsmakers favor them by -172 or more on the moneyline.
• The Red Sox's games have gone over the total in 57 of their 125 opportunities.
• The Red Sox are 61-64-0 against the spread in their 125 games that had a posted line this season.
• The Giants are 28-52 in games they were the underdog on the moneyline (winning 35% of those games).
• When playing as a moneyline underdog with odds of +158 or longer, San Francisco has gone 4-6 (40%).
• The Giants have had an over/under set by oddsmakers 124 times, and have combined with opponents to go over the total in 58 of those games (58-57-9).
• The Giants have covered 45.2% of their games this season, going 56-68-0 against the spread.

Red Sox Player Leaders

• Wilyer Abreu is batting .257 with 27 doubles, three triples, 22 home runs and 58 walks. He has an on-base percentage of .336 while slugging .467.
• Among qualifying hitters in baseball, his batting average ranks 71st, his on-base percentage ranks 65th, and he is 38th in slugging.
• Willson Contreras has 114 hits and an OBP of .393, both of which lead the Red Sox this season. He's batting .284 and slugging .534.
• Among qualified hitters, he ranks 21st in batting average, third in on-base percentage and eighth in slugging percentage.
• Contreras enters this matchup looking to extend his three-game hit streak. In his last five games he is hitting .368 with two doubles, a home run, four walks and three RBIs.
• Ceddanne Rafaela has hit 16 homers with a team-high .463 SLG this season.
• Caleb Durbin is batting .254 with a .325 OBP and 62 RBI for Boston this season.

Giants Player Leaders

• Jung Hoo Lee has put up an on-base percentage of .328 and a slugging percentage of .433. Both lead the Giants. He's batting .293.
• Including all the qualifying players in the big leagues, his batting average is 11th, his on-base percentage is 78th, and he is 64th in slugging.
• Lee enters this matchup on a four-game hitting streak. During his last five outings he is hitting .300 with a double and a walk.
• Rafael Devers is batting .244 with 31 doubles, a triple, 25 home runs and 54 walks. He's slugging .470 with an on-base percentage of .320.
• Including all qualifying hitters, he ranks 90th in batting average, 91st in on-base percentage and 34th in slugging percentage.
• Willy Adames is batting .229 with 25 doubles, a triple, 20 home runs and 36 walks.
• Bryce Eldridge is batting .247 with 15 doubles, 14 home runs and 43 walks.

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