Red Sox vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 2:12 a.m.

In MLB action on Friday, the Boston Red Sox take on the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Red Sox vs Giants Game Info

• Boston Red Sox (68-59) vs. San Francisco Giants (52-75)
• Date: Friday, August 21, 2026
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and NBCS-BA

Red Sox vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-178) | SF: (+150)
• Spread: BOS: -1.5 (+122) | SF: +1.5 (-146)
• Total: 7.5 -- Over: (-124) | Under: (+102)

Red Sox vs Giants Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Red Sox) - 15-3, 2.65 ERA vs Logan Webb (Giants) - 8-7, 3.50 ERA

The Red Sox will give the nod to Sonny Gray (15-3, 2.65 ERA), who is eyeing win No. 16 on the season, and the Giants will counter with Logan Webb (8-7, 3.50 ERA). Gray and his team are 15-7-0 ATS this season when he starts. Gray's team is 13-6 this season when he starts and they are the moneyline favorite. When Webb starts, the Giants have gone 10-12-0 against the spread. The Giants have a 2-6 record in Webb's eight starts this season when they were the moneyline underdog.

Red Sox vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (56.5%)

Red Sox vs Giants Moneyline

• Boston is the favorite, -178 on the moneyline, while San Francisco is a +150 underdog on the road.

Red Sox vs Giants Spread

• The Giants are at the Red Sox, and are +1.5 on the runline. The Giants are +122 to cover the spread, and the Red Sox are -146.

Red Sox vs Giants Over/Under

• The over/under for the Red Sox versus Giants game on Aug. 21 has been set at 7.5, with -124 odds on the over and +102 odds on the under.

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Red Sox vs Giants Betting Trends

• The Red Sox have won in 45, or 52.3%, of the 86 contests they have been named as odds-on favorites in this year.
• This season Boston has been victorious five times in eight chances when named as a favorite of at least -178 on the moneyline.
• The Red Sox and their opponents have gone over the total this season in 57 of their 125 opportunities.
• In 125 games with a line this season, the Red Sox have a mark of 61-64-0 against the spread.
• The Giants have won 35% of the games this season they were the underdog on the moneyline (28-52).
• When it has played as a moneyline underdog with odds of +150 or longer, San Francisco has a record of 8-6 (57.1%).
• The Giants have combined with opponents to go over the total 58 times this season for a 58-57-9 record against the over/under.
• The Giants have covered 45.2% of their games this season, going 56-68-0 against the spread.

Red Sox Player Leaders

• Wilyer Abreu is batting .257 with 27 doubles, three triples, 22 home runs and 58 walks. He has an on-base percentage of .336 while slugging .467.
• He ranks 71st in batting average, 65th in on-base percentage, and 38th in slugging among qualifying hitters in baseball.
• Willson Contreras leads Boston with 114 hits and an OBP of .393 this season. He's batting .284 and slugging .534.
• He ranks 21st in batting average, third in on-base percentage and eighth in slugging among qualified hitters.
• Contreras has picked up a hit in three games in a row. During his last five outings he is batting .368 with two doubles, a home run, four walks and three RBIs.
• Ceddanne Rafaela has hit 16 homers with a team-high .463 SLG this season.
• Caleb Durbin has 12 home runs, 62 RBI and a batting average of .254 this season.

Giants Player Leaders

• Jung Hoo Lee has accumulated an on-base percentage of .328 and a slugging percentage of .433. Both lead the Giants. He's batting .293.
• Including all qualified hitters in the big leagues, his batting average puts him 11th, his on-base percentage is 78th, and he is 64th in slugging.
• Lee brings a four-game hitting streak into this game. In his last five games he is hitting .300 with a double and a walk.
• Rafael Devers is batting .244 with 31 doubles, a triple, 25 home runs and 54 walks. He's slugging .470 with an on-base percentage of .320.
• Including all qualified players, he ranks 90th in batting average, 91st in on-base percentage and 34th in slugging percentage.
• Willy Adames has 25 doubles, a triple, 20 home runs and 36 walks while hitting .229.
• Bryce Eldridge is batting .247 with 15 doubles, 14 home runs and 43 walks.

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