Red Sox vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 10

Odds updated as of 5:12 a.m.

Friday's slate in the MLB includes a matchup between the Boston Red Sox and the St. Louis Cardinals.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Cardinals Game Info

• Boston Red Sox (4-8) vs. St. Louis Cardinals (7-5)
• Date: Friday, April 10, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and NESN

Red Sox vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-142) | STL: (+120)
• Spread: BOS: -1.5 (+122) | STL: +1.5 (-146)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Red Sox vs Cardinals Probable Starting Pitchers

Probable Pitchers: Connelly Early (Red Sox) - 0-0, 2.89 ERA vs Dustin May (Cardinals) - 0-2, 15.95 ERA

The Red Sox will give the ball to Connelly Early and the Cardinals will turn to Dustin May (0-2, 15.95 ERA). Early has a record of 0-2-0 ATS in two starts with a spread this season. Early's team is 0-2 this season when he starts and they're favored on the moneyline. May has started two games with set spreads, and the Cardinals failed to cover in both chances. The Cardinals were named the moneyline underdog for two May starts this season -- they lost both.

Red Sox vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (54.4%)

Red Sox vs Cardinals Moneyline

• Boston is a -142 favorite on the moneyline, while St. Louis is a +120 underdog at home.

Red Sox vs Cardinals Spread

• The Cardinals are hosting the Red Sox, and are +1.5 on the runline. The Cardinals are +122 to cover the spread, and the Red Sox are -146.

Red Sox vs Cardinals Over/Under

• The over/under for Red Sox-Cardinals on April 10 is 7.5. The over is -110, and the under is -110.

Bet on Boston Red Sox vs. St. Louis Cardinals on FanDuel today!

Red Sox vs Cardinals Betting Trends

• The Red Sox have been chosen as favorites in 10 games this year and have walked away with the win four times (40%) in those games.
• This year Boston has won three of six games when listed as at least -142 on the moneyline.
• Contests with the Red Sox have gone over the total set by oddsmakers in six of 12 chances this season.
• In 12 games with a line this season, the Red Sox have a mark of 3-9-0 against the spread.
• The Cardinals have gone 6-4 in games they were the underdog on the moneyline (winning 60% of those games).
• St. Louis has a 2-3 record (winning 40% of its games) when it has played as a moneyline underdog of +120 or longer.
• In the 12 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total six times (6-5-1).
• The Cardinals are 6-6-0 against the spread this season.

Red Sox Player Leaders

• Wilyer Abreu has 18 hits to go with a slugging percentage of .702, both of which lead Boston hitters this season. He has a .383 batting average and an on-base percentage of .408.
• Among all qualifying hitters in baseball, his batting average ranks fourth, his on-base percentage ranks 20th, and he is second in slugging.
• Willson Contreras leads Boston with an OBP of .434 this season while batting .250 with 11 walks and seven runs scored. He's slugging .425.
• Among all qualifying players, he ranks 74th in batting average, 12th in on-base percentage and 70th in slugging percentage.
• Contreras brings a three-game streak with at least one hit into this matchup. During his last five outings he is hitting .353 with a double, a home run, five walks and three RBIs.
• Ceddanne Rafaela has 11 hits this season and has a slash line of .324/.378/.412.
• Rafaela takes a five-game hitting streak into this game. In his last five games he is batting .467 with two walks and two RBIs.
• Masataka Yoshida has no home runs, but three RBI and a batting average of .250 this season.
• Yoshida has safely hit in two games in a row. During his last five outings he is hitting .308 with two doubles, five walks and three RBIs.

Cardinals Player Leaders

• Jordan Walker has accumulated a slugging percentage of .682 and has 13 hits, both team-high figures for the Cardinals. He's batting .295 and with an on-base percentage of .367.
• Including all qualified hitters in the big leagues, he ranks 34th in batting average, 47th in on-base percentage and fifth in slugging percentage.
• Walker takes a five-game hitting streak into this game. In his last five games he is batting .381 with four home runs, two walks and nine RBIs.
• Alec Burleson has a .400 OBP to lead his team. He has a batting average of .273 while slugging .386.
• He is 52nd in batting average, 23rd in on-base percentage and 84th in slugging percentage in MLB.
• JJ Wetherholt has a double, a home run and eight walks while hitting .244.
• Ivan Herrera is hitting .195 with three doubles and 12 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!