Purdue vs Iowa State College Basketball Prediction, Odds, Picks, Best Bets for Dec. 6

The Purdue Boilermakers (8-0) will try to extend an eight-game winning streak when they host the Iowa State Cyclones (8-0) on December 6, 2025. The Cyclones have also won eight games in a row.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Purdue vs. Iowa State Game Info and Odds

• Game day: Saturday, December 6, 2025
• Game time: 12 p.m. ET
• TV channel: CBS
• Location: West Lafayette, Indiana
• Arena: Mackey Arena

Purdue vs. Iowa State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Purdue win (68.2%)

Before placing a wager on Saturday's Purdue-Iowa State spread (Purdue -4.5) or over/under (154.5 points), take a look at the betting trends and insights below.

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Purdue vs. Iowa State: ATS Betting Stats and Trends

• Purdue has compiled a 4-4-0 ATS record so far this year.
• Iowa State is 6-2-0 ATS this year.
• At home last season, the Boilermakers sported a better record against the spread (10-6-0) compared to their ATS record in road games (6-5-0).
• The Cyclones' winning percentage against the spread at home was .529 (9-8-0) last year. Away, it was .636 (7-4-0).

Purdue vs. Iowa State: Moneyline Betting Stats

• Purdue has been named as the moneyline favorite four times this year and has yet to lose any of those games.
• The Boilermakers have been a -210 moneyline favorite on three occasions this season and won every game.
• Iowa State has not played as the moneyline underdog yet this season.
• The Cyclones have not yet played a game with moneyline odds of +168 or longer.
• The moneyline set for this matchup implies Purdue has a 67.7% chance of coming away with a victory in the contest.

Purdue vs. Iowa State Head-to-Head Comparison

• Purdue outscores opponents by 21 points per game (scoring 88.6 per game to rank 36th in college basketball while giving up 67.6 per contest to rank 73rd in college basketball) and has a +168 scoring differential overall.
• Fletcher Loyer's 15.6 points per game lead Purdue and are 238th in college basketball.
• Iowa State has a +247 scoring differential, topping opponents by 30.9 points per game. It is putting up 96.3 points per game, fourth in college basketball, and is allowing 65.4 per outing to rank 33rd in college basketball.
• Joshua Jefferson's team-leading 18.4 points per game rank him 80th in college basketball.
• The Boilermakers grab 38.1 rebounds per game (32nd in college basketball) while allowing 26.9 per outing to their opponents. They outrebound opponents by 11.2 boards per game.
• Trey Kaufman-Renn is ninth in college basketball play with 11 rebounds per game to lead the Boilermakers.
• The Cyclones win the rebound battle by 6.3 boards on average. They record 32.6 rebounds per game, 218th in college basketball, while their opponents pull down 26.3.
• Jefferson tops the Cyclones with 7.3 rebounds per game (138th in college basketball).
• Purdue's 113.2 points per 100 possessions on offense rank ninth in college basketball, and the 86.3 points it allows per 100 possessions rank 86th in college basketball.
• The Cyclones' 117.9 points per 100 possessions on offense rank second in college basketball, and the 80.1 points they allow per 100 possessions rank 17th in college basketball.

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