Michigan State vs Duke College Basketball Prediction, Odds, Picks, Best Bets for Dec. 6

Two streaking teams meet when the Duke Blue Devils (9-0) visit the Michigan State Spartans (8-0) on December 6, 2025. The Blue Devils will put their nine-game win streak on the line against the Spartans, who have won eight straight.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Michigan State Game Info and Odds

• Game day: Saturday, December 6, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: East Lansing, Michigan
• Arena: Jack Breslin Students Events Center

Duke vs. Michigan State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Michigan State win (59.1%)

See these betting trends and insights before you wager on Saturday's Duke-Michigan State spread (Duke -1.5) or over/under (140.5 points).

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Duke vs. Michigan State: ATS Betting Stats and Trends

• Duke has compiled a 5-4-0 record against the spread this season.
• Michigan State has won five games against the spread this season, while failing to cover three times.
• Duke (5-4) covers a lower percentage of games when it is favored by 1.5 points or more this season (55.6%) than Michigan State (1-0) does as a 1.5+-point underdog (100%).
• The Blue Devils did a better job covering the spread when playing on the road (9-2-0) than they did at home (11-6-0) last season.
• Against the spread last year, the Spartans had better results on the road (7-2-0) than at home (10-6-0).

Duke vs. Michigan State: Moneyline Betting Stats

• Duke has been listed as the moneyline favorite four times this season and has come away with a win in all of those games.
• The Blue Devils have not lost in four games this year when favored by -120 or better on the moneyline.
• Michigan State has been listed as the moneyline underdog only one other time so far this season, a game it won.
• The Spartans have played as a moneyline underdog of +100 or longer in just one game this season, which they won.
• The moneyline set for this matchup implies Duke has a 54.5% chance of walking away with the win.

Duke vs. Michigan State Head-to-Head Comparison

• Duke outscores opponents by 29.5 points per game (scoring 89.1 per game to rank 32nd in college basketball while giving up 59.6 per contest to rank fifth in college basketball) and has a +266 scoring differential overall.
• Cameron Boozer's team-leading 23.6 points per game ranks second in the country.
• Michigan State is outscoring opponents by 18.2 points per game, with a +146 scoring differential overall. It puts up 78.6 points per game (166th in college basketball) and gives up 60.4 per outing (sixth in college basketball).
• Jaxon Kohler's 14.3 points per game leads Michigan State and ranks 367th in college basketball.
• The 39.1 rebounds per game the Blue Devils average rank 22nd in college basketball, and are 10.3 more than the 28.8 their opponents grab per outing.
• Boozer averages 9.3 rebounds per game (ranking 30th in college basketball) to lead the Blue Devils.
• The Spartans grab 38.3 rebounds per game (29th in college basketball) while conceding 25 per contest to opponents. They outrebound opponents by 13.3 boards per game.
• Kohler is 23rd in the nation with 9.9 rebounds per game, leading the Spartans.
• Duke ranks 19th in college basketball with 110.8 points scored per 100 possessions, and first in college basketball defensively with 74.1 points conceded per 100 possessions.
• The Spartans' 102.7 points per 100 possessions on offense rank 93rd in college basketball, and the 78.9 points they concede per 100 possessions rank 11th in college basketball.

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