Pittsburgh vs Syracuse Prediction, Odds, Picks, Best Bets for Week 3 2026

The college football slate on Thursday includes the Pittsburgh Panthers taking on the Syracuse Orange.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Pittsburgh vs Syracuse Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Pittsburgh: (-400) | Syracuse: (+310)
• Spread: Pittsburgh: -10.5 (100) | Syracuse: +10.5 (-122)
• Total: 51.5 -- Over: (-105) | Under: (-115)

Pittsburgh vs Syracuse Betting Trends

• Pittsburgh has one win against the spread this year.
• Pittsburgh is unbeaten ATS (1-0) as a 10.5-point favorite or greater this season.
• One of two Pittsburgh games have gone over the point total this season.
• Syracuse has one win against the spread this season.
• Syracuse has had one game (of two) hit the over this season.

Pittsburgh vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Panthers win (91.6%)

Pittsburgh vs Syracuse Point Spread

Pittsburgh is favored by 10.5 points versus Syracuse. Pittsburgh is +100 to cover the spread, while Syracuse is -122.

Pittsburgh vs Syracuse Over/Under

The Pittsburgh-Syracuse matchup on Sept. 17 has been given an over/under of 51.5 points. The over is -105 and the under is -115.

Pittsburgh vs Syracuse Moneyline

The moneyline numbers for Pittsburgh vs. Syracuse reveal Pittsburgh as the favorite (-400) and Syracuse as the underdog (+310).

Pittsburgh vs. Syracuse Points Insights

Pittsburgh vs. Syracuse Game Info

• Game day: Thursday, September 17, 2026
• Game time: 7:30 p.m. ET
• TV channel: ESPN
• Location: Pittsburgh, Pennsylvania
• Stadium: Acrisure Stadium

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Check out even more in-depth Pittsburgh vs. Syracuse analysis on FanDuel Research.