Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 28

Odds updated as of 8:12 p.m.

The Pittsburgh Pirates versus the St. Louis Cardinals is on the MLB schedule for Friday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (65-70) vs. St. Louis Cardinals (67-68)
• Date: Friday, August 28, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and SportsNet PT

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-112) | STL: (+104)
• Spread: PIT: -1.5 (+146) | STL: +1.5 (-178)
• Total: 7.5 -- Over: (-102) | Under: (-120)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jared Jones (Pirates) - 2-5, 4.76 ERA vs Quinn Mathews (Cardinals) - 0-2, 6.43 ERA

The probable pitchers are Jared Jones (2-5) for the Pirates and Quinn Mathews (0-2) for the Cardinals. Jones and his team have a record of 7-8-0 against the spread when he starts. Jones' team has won 40% of his starts when they are favored on the moneyline (2-3). The Cardinals did not cover in any of Mathews' three starts that had a set spread. The Cardinals were named the moneyline underdog for two Mathews starts this season -- they lost both.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51.7%)

Pirates vs Cardinals Moneyline

• Pittsburgh is a -112 favorite on the moneyline, while St. Louis is a +104 underdog at home.

Pirates vs Cardinals Spread

• The Pirates are 1.5-run road favorites on the runline against the Cardinals. The Pirates are +146 to cover, and the Cardinals are -178.

Pirates vs Cardinals Over/Under

• Pirates versus Cardinals on Aug. 28 has an over/under of 7.5 runs, with the odds on the over -102 and the under set at -120.

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Pirates vs Cardinals Betting Trends

• The Pirates have been chosen as favorites in 68 games this year and have walked away with the win 38 times (55.9%) in those games.
• This year Pittsburgh has won 36 of 65 games when listed as at least -112 on the moneyline.
• The Pirates and their opponents have hit the over in 72 of their 133 games with a total set by oddsmakers this season.
• The Pirates have posted a record of 65-68-0 against the spread this season.
• The Cardinals are 41-48 in games they were listed as the moneyline underdog (winning 46.1% of those games).
• When it has played as a moneyline underdog with odds of +104 or longer, St. Louis has a 33-34 record (winning 49.3% of its games).
• The Cardinals have played in 131 games with a set over/under, and have combined with opponents to go over the total 57 times (57-67-7).
• The Cardinals have covered 53.4% of their games this season, going 70-61-0 against the spread.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh in OBP (.370) this season, fueled by 131 hits. He has a .263 batting average and a slugging percentage of .425.
• Among qualifying hitters, he is 55th in batting average, his on-base percentage ranks 16th, and he is 65th in slugging.
• Reynolds hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .250 with a double and two walks.
• Brandon Lowe has 123 hits, which is best among Pittsburgh batters this season. He's batting .249 with 54 extra-base hits. He's also slugging .470 with an on-base percentage of .316.
• His batting average ranks 81st among qualified players, his on-base percentage 96th, and his slugging percentage 35th.
• Nick Gonzales leads Pittsburgh in slugging percentage (.394) powered by 29 extra-base hits.
• Spencer Horwitz has been key for Pittsburgh with 80 hits, an OBP of .356 plus a slugging percentage of .394.
• Horwitz heads into this matchup on a four-game hitting streak. During his last five outings he is batting .227 with a walk.

Cardinals Player Leaders

• Alec Burleson has a team-best .484 slugging percentage. He's batting .292 with an on-base percentage of .356.
• Including all qualified players, he is ninth in batting average, while his on-base percentage is 38th and he is 24th in slugging.
• Burleson enters this game on a 13-game hitting streak. In his last 10 games he is hitting .316 with a double, a walk and seven RBIs.
• Jordan Walker leads his team with 146 hits. He has a batting average of .286 while slugging .502 with an on-base percentage of .345.
• Including all qualified hitters, he is 16th in batting average, 50th in on-base percentage and 16th in slugging percentage.
• JJ Wetherholt is batting .245 with 14 doubles, 17 home runs and 63 walks.
• Ivan Herrera's .361 OBP leads his team.

Pirates vs Cardinals Head to Head

• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/27/2026: 4-2 STL (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/28/2025: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/27/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)

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