Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 28

Odds updated as of 7:13 a.m.

The Pittsburgh Pirates will take on the St. Louis Cardinals in MLB action on Friday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (65-70) vs. St. Louis Cardinals (67-68)
• Date: Friday, August 28, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and SportsNet PT

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-116) | STL: (-102)
• Spread: PIT: -1.5 (+155) | STL: +1.5 (-188)
• Total: 7 -- Over: (-122) | Under: (+100)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jared Jones (Pirates) - 2-5, 4.76 ERA vs Quinn Mathews (Cardinals) - 0-2, 6.43 ERA

The Pirates will give the nod to Jared Jones (2-5) against the Cardinals and Quinn Mathews (0-2). Jones and his team have a record of 7-8-0 against the spread when he starts. Jones' team has a record of 2-3 this season when he starts and they are the favorite on the moneyline. In each of Mathews' three starts that had a set spread, the Cardinals failed to cover. The Cardinals were named the moneyline underdog for two Mathews starts this season -- they lost both.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51.1%)

Pirates vs Cardinals Moneyline

• St. Louis is the underdog, -102 on the moneyline, while Pittsburgh is a -116 favorite despite being on the road.

Pirates vs Cardinals Spread

• The Pirates are 1.5-run road favorites on the runline against the Cardinals. The Pirates are +155 to cover, and the Cardinals are -188.

Pirates vs Cardinals Over/Under

• The over/under for Pirates-Cardinals on Aug. 28 is 7. The over is -122, and the under is +100.

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Pirates vs Cardinals Betting Trends

• The Pirates have been victorious in 38, or 55.9%, of the 68 contests they have been chosen as favorites in this season.
• This year Pittsburgh has won 33 of 62 games when listed as at least -116 on the moneyline.
• The Pirates' games have gone over the total in 72 of their 133 opportunities.
• The Pirates have posted a record of 65-68-0 against the spread this season.
• The Cardinals have won 46.1% of the games this season they were the moneyline underdog (41-48).
• St. Louis is 35-41 (winning 46.1% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Cardinals have played in 131 games with a set over/under, and have combined with opponents to go over the total 57 times (57-67-7).
• The Cardinals are 70-61-0 against the spread this season.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with an OBP of .370 this season while batting .263 with 77 walks and 88 runs scored. He has a slugging percentage of .425.
• Among qualifying batters in baseball, he ranks 55th in batting average, 16th in on-base percentage, and 66th in slugging.
• Reynolds will look for his fourth straight game with a hit in this matchup. During his last five outings he is hitting .250 with a double and two walks.
• Brandon Lowe leads Pittsburgh in total hits (123) this season while batting .249 with 54 extra-base hits. He's slugging .470 with an on-base percentage of .316.
• Among qualifying batters, his batting average ranks him 81st, his on-base percentage 95th, and his slugging percentage 35th.
• Nick Gonzales leads Pittsburgh in slugging percentage (.394) powered by 29 extra-base hits.
• Spencer Horwitz has 10 home runs, 38 RBI and a batting average of .254 this season.
• Horwitz takes a four-game hitting streak into this game. In his last five games he is batting .227 with a walk.

Cardinals Player Leaders

• Alec Burleson has a .484 slugging percentage, which leads the Cardinals. He's batting .292 with an on-base percentage of .356.
• He is ninth in batting average, 38th in on-base percentage and 24th in slugging percentage among all qualifying hitters in MLB.
• Burleson takes a 13-game hitting streak into this game. In his last 10 outings he is batting .316 with a double, a walk and seven RBIs.
• Jordan Walker's 146 hits lead his team. He has a batting average of .286 while slugging .502 with an on-base percentage of .345.
• His batting average ranks 16th among all qualified players, his on-base percentage is 50th, and he is 16th in slugging.
• JJ Wetherholt is batting .245 with 14 doubles, 17 home runs and 63 walks.
• Ivan Herrera paces his team with a .361 OBP.

Pirates vs Cardinals Head to Head

• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/27/2026: 4-2 STL (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/28/2025: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/27/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)

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