Penn State vs USC Prediction, Odds, Picks, Best Bets for Week 6 2026

The Penn State Nittany Lions are among the college football squads busy on Saturday, up against the USC Trojans.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Penn State vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (-118) | USC: (+100)
• Spread: Penn State: -1.5 (-106) | USC: +1.5 (-114)
• Total: 54.5 -- Over: (-118) | Under: (-104)

Penn State vs USC Betting Trends

• Penn State has two wins against the spread this year.
• Penn State has won twice ATS (2-3) as a 1.5-point or bigger favorite this season.
• This year, three of Penn State's five games have hit the over.
• USC has posted one win against the spread this year.
• USC is winless ATS (0-1) when playing as at least 1.5-point underdogs this year.
• There have been four USC games (out of six) that hit the over this season.

Penn State vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (72.1%)

Penn State vs USC Point Spread

Penn State is favored by 1.5 points over USC. Penn State is -106 to cover the spread, with USC being -114.

Penn State vs USC Over/Under

The Penn State-USC game on Oct. 10 has been given an over/under of 54.5 points. The over is -118 and the under is -104.

Penn State vs USC Moneyline

USC is a +100 underdog on the moneyline, while Penn State is a -118 favorite.

Penn State vs. USC Points Insights

Penn State vs. USC Game Info

• Game day: Saturday, October 10, 2026
• Game time: 7:30 p.m. ET
• TV channel: NBC/Peacock
• Location: University Park, Pennsylvania
• Stadium: West Shore Home Field at Beaver Stadium

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Check out even more in-depth Penn State vs. USC analysis on FanDuel Research.