Penguins vs Sabres NHL Prediction, Odds, Picks, Best Bets for Nov. 26

The Pittsburgh Penguins versus the Buffalo Sabres is on the NHL schedule for Wednesday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Penguins vs Sabres Game Info

• Pittsburgh Penguins (10-6-5) vs. Buffalo Sabres (9-9-4)
• Date: Wednesday, November 26, 2025
• Time: 7 p.m. ET
• Venue: PPG Paints Arena -- Pittsburgh, Pennsylvania
• Coverage: ESPN+

Penguins vs Sabres Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Penguins vs Sabres Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Penguins win (64%)

Penguins vs Sabres Puck Line

• The Penguins are favored by 1.5 goals. The Penguins are +210 to cover the spread, with the Sabres being -265.

Penguins vs Sabres Over/Under

• A combined goal total of 6.5 has been set for Penguins-Sabres on Nov. 26, with the over at +100 and the under at -122.

Penguins vs Sabres Moneyline

• Pittsburgh is a -118 favorite on the moneyline, while Buffalo is a -102 underdog on the road.

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