Panthers vs Flyers NHL Prediction, Odds, Picks, Best Bets for Nov. 26

The Florida Panthers are among the NHL squads busy on Wednesday, up against the Philadelphia Flyers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Panthers vs Flyers Game Info

• Florida Panthers (12-9-1) vs. Philadelphia Flyers (11-7-3)
• Date: Wednesday, November 26, 2025
• Time: 7 p.m. ET
• Venue: Amerant Bank Arena -- Sunrise, Florida
• Coverage: ESPN+

Panthers vs Flyers Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Panthers vs Flyers Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Panthers win (61.1%)

Panthers vs Flyers Puck Line

• The Panthers are 1.5-goal favorites against the Flyers. The Panthers are +148 to cover the spread, and the Flyers are -184.

Panthers vs Flyers Over/Under

• Panthers versus Flyers, on Nov. 26, has an over/under of 5.5, with the over being -110 and the under -110.

Panthers vs Flyers Moneyline

• Florida is the favorite, -176 on the moneyline, while Philadelphia is a +146 underdog on the road.

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