Patrick Mahomes Fantasy Football Week 2: Stats and Projections vs. Colts

Kansas City Chiefs QB Patrick Mahomes will take on the team with last year's 30th-ranked passing defense, the Indianapolis Colts (247.9 yards allowed per game), in Week 2 -- kicking off at 8:20 p.m. ET on Sunday.

Is Mahomes a daily fantasy option for you this week, as he plays the Colts? More stats and info can be found below, so check it out.

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Patrick Mahomes Week 2 Fantasy Football Projection

• Matchup: Kansas City Chiefs vs. Indianapolis Colts
• Game Date: September 20, 2026
• Game Time: 8:20 p.m.
• Projected Fantasy Points: 22.7
• Projected Passing Yards: 332.39
• Projected Passing TDs: 2.40
• Projected Rushing Yards: 10.95
• Projected Rushing TDs: 0.11

Projections provided by numberFire

Mahomes 2025 Fantasy Performance

• Ranked 15th overall and 11th at his position, Mahomes picked up 284.7 fantasy points (20.3 per game) in 2025.
• Mahomes picked up 21.7 fantasy points in his one game this year. He connected on 15 of 27 passes for 184 yards, throwing for two touchdowns with one interception, and ran for 23 yards on seven carries tacking on one TD.
• Mahomes picked up 31.5 fantasy points -- 22-of-30 (73.3%), 257 yards, 3 TDs, 0 INTs; 10 carries, 32 yards, 1 TD -- in Week 6 against the Detroit Lions, which was his best game last year.
• In his second-best game of the year -- Week 13 versus the Dallas Cowboys -- Mahomes finished with 29.4 fantasy points. His stat line: 23-of-34 (67.6%), 261 yards, 4 TDs, 0 INTs; 3 carries, 30 yards.
• In his worst game of the season -- Week 14 against the Houston Texans -- Mahomes finished with 5.3 fantasy points. His stat line was: 14-of-33 (42.4%), 160 yards, 0 TDs, 3 INTs; 7 carries, 59 yards.
• His second-lowest fantasy point total -- 10.5 -- was in Week 9 against the Buffalo Bills, when Mahomes put together this stat line: 15-of-34 (44.1%), 250 yards, 0 TDs, 1 INT.

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Colts Defensive Performance

• Last season, Indianapolis allowed four quarterbacks to rack up over 300 passing yards in a game.
• 12 players have thrown for at least one touchdown in a tilt against the Colts last year.
• Through the air last season, Indianapolis allowed two or more touchdown passes to six opposing QBs.
• In the passing game, the Colts allowed at least three passing touchdowns to four opposing quarterbacks last year.
• Against Indianapolis last season, eight players put up more than 100 receiving yards in a game.
• In terms of pass defense, the Colts allowed a touchdown reception to 23 players last season.
• Indianapolis allowed two or more receiving touchdowns through the air to just one player last season.
• In the run game, two players recorded more than 100 rushing yards in a game against the Colts last season.
• Against Indianapolis last season, 12 players rushed for at least one TD.
• On the ground, the Colts allowed four players to score at least two rushing touchdowns against them last year.

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