Patrick Mahomes Fantasy Football Week 2: Stats and Projections vs. Colts

Kansas City Chiefs quarterback Patrick Mahomes will take on the team with last season's 30th-ranked pass defense, the Indianapolis Colts (247.9 yards allowed per game), in Week 2 -- beginning at 8:20 p.m. ET on Sunday.

With Mahomes' next game versus the Colts, should you think about him for your daily fantasy roster? Scroll down for more stats and information.

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Patrick Mahomes Week 2 Fantasy Football Projection

• Matchup: Kansas City Chiefs vs. Indianapolis Colts
• Game Date: September 20, 2026
• Game Time: 8:20 p.m.
• Projected Fantasy Points: 18.5
• Projected Passing Yards: 239.20
• Projected Passing TDs: 1.73
• Projected Rushing Yards: 21.57
• Projected Rushing TDs: 0.23

Projections provided by numberFire

Mahomes 2025 Fantasy Performance

• Ranked 15th overall and 11th at his position, Mahomes accumulated 284.7 fantasy points (20.3 per game) in 2025.
• In his one game this season, Mahomes accumulated 21.7 fantasy points. He finished 15-of-27 for 184 yards, with two touchdowns and one interception and has rushed for 23 yards on seven carries with one TD.
• Mahomes accumulated 31.5 fantasy points -- 22-of-30 (73.3%), 257 yards, 3 TDs, 0 INTs; 10 carries, 32 yards, 1 TD -- in Week 6 versus the Detroit Lions, which was his best game last year.
• Mahomes recorded 29.4 fantasy points (23-of-34 (67.6%), 261 yards, 4 TDs, 0 INTs; 3 carries, 30 yards) in Week 13 versus the Dallas Cowboys, his second-best game last season.
• In his worst game of the year -- Week 14 against the Houston Texans -- Mahomes finished with 5.3 fantasy points. His stat line was: 14-of-33 (42.4%), 160 yards, 0 TDs, 3 INTs; 7 carries, 59 yards.
• In his second-worst game of the year (Week 9 against the Buffalo Bills), Mahomes finished with 10.5 fantasy points -- 15-of-34 (44.1%), 250 yards, 0 TDs, 1 INT.

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Colts Defensive Performance

• Indianapolis allowed more than 300 passing yards to four QBs last year.
• The Colts gave up at least one passing TD to 12 opposing QBs last season.
• In the passing game, Indianapolis allowed six players to throw two or more touchdowns in a game last year.
• In the passing game, the Colts gave up at least three passing touchdowns to four opposing quarterbacks last year.
• Indianapolis let eight players amass more than 100 receiving yards in a game last year.
• Against the Colts last season, 23 players caught a TD pass.
• Against Indianapolis last year, one player hauled in more than one touchdown pass in a game.
• On the ground, two players put up more than 100 rushing yards in a game against the Colts last season.
• On the ground, Indianapolis allowed 12 players to score at least one rushing touchdown against them last season.
• Four players ran for multiple scores in a game against the Colts last year.

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