Padres vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 9:12 p.m.

MLB action on Friday includes the San Diego Padres playing the Minnesota Twins.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Twins Game Info

• San Diego Padres (68-60) vs. Minnesota Twins (63-65)
• Date: Friday, August 21, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Twins.TV

Padres vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-116) | MIN: (+108)
• Spread: SD: +1.5 (-205) | MIN: -1.5 (+168)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Padres vs Twins Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 8-6, 4.30 ERA vs Connor Prielipp (Twins) - 3-6, 5.34 ERA

This contest's pitching matchup is set, as the Padres will send Randy Vasquez (8-6) to the mound, while Connor Prielipp (3-6) will get the nod for the Twins. Vasquez and his team are 13-6-0 ATS this season when he starts. When Vasquez starts a game and his team is the favorite on the moneyline, they have a record of 5-2. The Twins have a 10-7-0 record against the spread in Prielipp's starts. The Twins have been the underdog on the moneyline in 13 of Prielipp's starts this season, and they went 3-10 in those games.

Padres vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.8%)

Padres vs Twins Moneyline

• The Padres vs Twins moneyline has San Diego as a -116 favorite, while Minnesota is a +108 underdog on the road.

Padres vs Twins Spread

• The Twins are 1.5-run favorites against the spread for this matchup with the Padres. The Twins are +168 to cover, while the Padres are -205 to cover as a 1.5-run underdog on the runline.

Padres vs Twins Over/Under

• A combined run total of 8.5 has been set for Padres-Twins on Aug. 21, with the over at +100 and the under at -122.

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Padres vs Twins Betting Trends

• The Padres have been chosen as favorites in 54 games this year and have walked away with the win 30 times (55.6%) in those games.
• This season San Diego has come away with a win 27 times in 47 chances when named as a favorite of at least -116 on the moneyline.
• The Padres and their opponents have gone over the total this season in 56 of their 128 opportunities.
• The Padres have an against the spread record of 73-55-0 in 128 games with a line this season.
• The Twins have gone 36-42 in games they were the underdog on the moneyline (winning 46.2% of those games).
• In games it has played as a moneyline underdog with odds of +108 or longer, Minnesota has a 30-31 record (winning 49.2% of its games).
• The Twins have played in 125 games with a set over/under, and have combined with opponents to go over the total 69 times (69-53-3).
• The Twins have covered 55.2% of their games this season, going 69-56-0 against the spread.

Padres Player Leaders

• Fernando Tatis Jr. has 137 hits and an OBP of .354 to go with a slugging percentage of .434. All three of those stats are best among San Diego hitters this season. He has a .280 batting average, as well.
• Among all qualifying hitters in baseball, he ranks 26th in batting average, 41st in on-base percentage, and 61st in slugging.
• Tatis will look for his third straight game with a hit in this contest. During his last five outings he is hitting .278 with a double, two home runs, three walks and five RBIs.
• Manny Machado has 20 doubles, 24 home runs and 58 walks. He's batting .215 and slugging .413 with an on-base percentage of .299.
• His batting average ranks 134th among qualified players, his on-base percentage 123rd, and his slugging percentage 86th.
• Jackson Merrill has collected 116 base hits, an OBP of .290 and a slugging percentage of .408 this season.
• Xander Bogaerts has been key for San Diego with 91 hits, an OBP of .320 plus a slugging percentage of .329.

Twins Player Leaders

• Josh Bell has accumulated a slugging percentage of .433, a team-best for the Twins. He's batting .258 with an on-base percentage of .321.
• Including all qualified players in the big leagues, he is 71st in batting average, 89th in on-base percentage and 64th in slugging percentage.
• Bell takes a five-game hitting streak into this game. During his last five outings he is batting .389 with two doubles, a home run, two walks and five RBIs.
• Brooks Lee is hitting .244 with 19 doubles, three triples, 18 home runs and 33 walks. He's slugging .419 with an on-base percentage of .299.
• Including all qualified hitters, his batting average puts him 90th, his on-base percentage ranks 123rd, and he is 81st in slugging.
• Kody Clemens is leading the Twins with 97 hits.
• Luke Keaschall leads his team with a .364 on-base percentage.

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