Odds updated as of 6:11 PM

The Wednesday slate in MLB includes a matchup between the San Diego Padres and the Cincinnati Reds.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Reds Game Info

• San Diego Padres (25-26) vs. Cincinnati Reds (20-28)
• Date: Wednesday, May 22, 2024
• Time: 6:40 PM ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: BSOH

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-132) | CIN: (+112)
• Spread: SD: -1.5 (+125) | CIN: +1.5 (-150)
• Total: 9.5 -- Over: (-102) | Under: (-120)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 3-4, 4.31 ERA vs Nick Martínez (Reds) - 1-2, 4.23 ERA

The Padres will call on Michael King (3-4) against the Reds and Nick Martinez (1-2). King's team is 5-4-0 against the spread this season in his starts. King's team is 1-3 this season when he starts and they are the moneyline favorite. The Reds are 1-3-0 ATS in Martínez's four starts with a set spread. The Reds were the moneyline underdog for two Martinez starts this season -- they lost both.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.2%)

Padres vs Reds Moneyline

• Cincinnati is a +112 underdog on the moneyline, while San Diego is a -132 favorite on the road.

Padres vs Reds Spread

• The Reds are at +1.5 on the runline against the Padres. The Reds are -150 to cover the spread, and the Padres are +125.

Padres vs Reds Over/Under

• The Padres-Reds contest on May 22 has been given an over/under of 9.5 runs. The over is set at -102 and the under at -120.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have come away with 13 wins in the 29 contests they have been listed as the favorites in this season.
• This year San Diego has won nine of 18 games when listed as at least -132 on the moneyline.
• The Padres and their opponents have gone over in 25 of their 50 games with a total set by sportsbooks this season.
• The Padres have posted a record of 23-27-0 against the spread this season.
• The Reds have been the moneyline underdog 27 total times this season. They've gone 8-19 in those games.
• Cincinnati is 3-12 (winning just 20% of its games) when playing as a moneyline underdog of +112 or longer.
• The Reds have played in 46 games with a set over/under, and have combined with opponents to go over the total 22 times (22-22-2).
• The Reds have a 25-21-0 record against the spread this season (covering 54.3% of the time).

Padres Player Leaders

• Jurickson Profar leads San Diego with 58 hits and an OBP of .427 this season. He has a .339 batting average and a slugging percentage of .515.
• He is second in batting average, second in on-base percentage, and 18th in slugging among qualified hitters in baseball.
• Profar hopes to build on a 10-game hitting streak in this matchup. In his last 10 outings he is batting .400 with a double, a home run, seven walks and four RBI.
• Jake Cronenworth is hitting .269 with 10 doubles, a triple, eight home runs and 18 walks. He's slugging .467 with an on-base percentage of .338.
• Among all qualifying batters, he is 42nd in batting average, 51st in on-base percentage and 38th in slugging percentage.
• Fernando Tatis Jr. is batting .249 with a .416 slugging percentage and 24 RBI this year.
• Luis Arraez leads San Diego in slugging percentage (.383) thanks to 12 extra-base hits.
• Arraez enters this game on a six-game hitting streak. In his last 10 outings he is hitting .341 with two doubles, two walks and three RBI.

Reds Player Leaders

• Elly De La Cruz has racked up 45 hits with a .355 on-base percentage and a .483 slugging percentage, all club-bests for the Reds. He's batting .262.
• Including all qualifying hitters in the big leagues, his batting average places him 58th, his on-base percentage is 30th, and he is 29th in slugging.
• Spencer Steer has 10 doubles, a triple, four home runs and 24 walks while batting .224. He's slugging .373 with an on-base percentage of .337.
• He is 116th in batting average, 53rd in on-base percentage and 113th in slugging percentage in MLB.
• Tyler Stephenson is hitting .263 with seven doubles, five home runs and 13 walks.
• Jonathan India is batting .216 with three doubles, a triple, two home runs and 23 walks.

Padres vs Reds Head to Head

• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2024: 5-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/2/2023: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 11, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/1/2023: 12-5 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/30/2023: 7-5 CIN (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/3/2023: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 5/2/2023: 2-1 CIN (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/1/2023: 8-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)

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